SML1042
醋酸依替巴肽
≥98% (HPLC)
别名:
N6-（氨基亚氨基甲基）-N2-（3-巯基-1-氧丙基）-L-赖氨酰基-L- α-天冬氨酰-L-色氨酸-L-脯氨酰基-L-半胱胺酸环状（16）-二硫乙酸, 环（S，S）-Mpr（Har）GDWPC-NH2乙酸盐
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 2 mg/mL, clear (warmed)
运输
wet ice
储存温度
−20°C
相关类别
一般描述
醋酸依替巴肽是一种环七肽。它属于精氨酸-甘氨酸-天冬氨酸类似物。依替巴肽的半衰期很短。该药物可降低心肌梗死（MI）的风险。醋酸依替巴肽可能与血小板减少症有关。
生化/生理作用
依替巴肽是纤维蛋白原与血小板膜整合素糖蛋白GPIIb/IIIa受体结合的特异性抑制剂。
依替巴肽是纤维蛋白原与血小板膜整合素糖蛋白GPIIb/IIIa受体结合的特异性抑制剂，可预防血小板聚集。依替巴肽进行可逆的竞争性结合。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Recurrent acute thrombocytopenia in the hospitalized patient: Sepsis, DIC, HIT, or antibiotic-induced thrombocytopenia
Rousan TA, et al.
American Journal of Hematology, 85(1), 71-74 (2010)
Current role of platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes
Bhatt DL and Topol EJ
JAMA : The Journal of the American Medical Association, 284(12), 1549-1558 (2000)
Eptifibatide: A cyclic peptide that selectively inhibits platelet glycoprotein IIb/IIIa
Heras M and Escolar G
Drugs Today (Barc), 36, 295-311 (2000)
Clinical review: traumatic brain injury in patients receiving antiplatelet medication
Beynon C, et al.
Critical Care, 16(4), 228-228 (2012)
Jaqueline Gomes Rosa et al.
Toxicon : official journal of the International Society on Toxinology, 159, 50-60 (2019-01-25)
Victims of Bothrops jararaca snakebites manifest bleedings, blood incoagulability, platelet dysfunction, and thrombocytopenia, and the latter has been directly implicated in the genesis of hemorrhagic diathesis. We addressed herein the direct effects of B. jararaca venom (BjV) on ex vivo
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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