SML1058
PBIT
≥98% (HPLC)
别名:
2-对甲苯基-1,2-苯并噻唑啉-3-酮, 2-（4-甲基苯基）-1，2-苯并噻唑-3（2H）-1； 2-（4-甲基苯基）-2,3-二氢苯并噻唑-3-酮
SMILES string
[s]1[n]([c](c3c1cccc3)=O)c2ccc(cc2)C
InChI
1S/C14H11NOS/c1-10-6-8-11(9-7-10)15-14(16)12-4-2-3-5-13(12)17-15/h2-9H,1H3
InChI key
KRXMYBAZKJBJAB-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
S,S′-1,4-亚苯基双（1,2-乙二基）双异硫脲（PBIT）是一种 iNOS（诱导型一氧化氮合酶）抑制剂。它能够抑制JARIDB1 高表达的乳腺癌细胞系的增殖。
PBIT 是 JARID1B（KDM5B）的有效抑制剂。
PBIT 是 JARID1B（KDM5B）组蛋白赖氨酸脱甲基酶的有效抑制剂，可抑制 UACC-812 细胞中 H3K4me3 的去除。PBIT 抑制过表达 JARID1B 的细胞的增殖。PBIT 对 JARID1 酶具有选择性，并且不抑制 UTX 或 JMJD3 脱甲基酶。
Features and Benefits
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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