SML1059
MMB-4
≥98% (HPLC), cholinesterases reactivator, powder
别名:
1,1′-Methylenebis[4-[(hydroxyimino)methyl]-pyridinium dibromide
产品名称
MMB-4, ≥98% (HPLC)
SMILES string
O/N=C/C1=CC=[N+](C[N+]2=CC=C(/C=N\O)C=C2)C=C1.[Br-].[Br-]
InChI
1S/C13H12N4O2.2BrH/c18-14-9-12-1-5-16(6-2-12)11-17-7-3-13(4-8-17)10-15-19;;/h1-10H,11H2;2*1H
InChI key
ZKQNRRLCBJUEBC-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
light yellow to light brown
solubility
H2O: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
MMB-4 is also called as 1,1′-Methylenebis{4-[(hydroxyimino)methyl]pyridinium) dichloride. It serves as a promising antidote for organophosphate poisoning.
MMB-4 is an oxime that can reactivate cholinesterases that have been inactivated by exposure to organophosphates such as sarin or soman. Administration of MMB-4 and atropine normalizes many respiratory parameters in guinea pigs following soman inhalation.
MMB-4 is an oxime that can reactivate cholinesterases.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Patrick Macauley et al.
Journal of pharmaceutical and biomedical analysis, 49(4), 889-894 (2009-02-17)
1,1'-Methylenebis{4-[(hydroxyimino)methyl]pyridinium) dichloride (MMB-4), a promising antidote for organophosphate poisoning, has been shown by chromatography and NMR to be a mixture of geometric isomers, predominantly the E/E form. The chromatographically separated isomers have been isolated, directly characterized by NMR to be
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