塞来昔布-NBD

Name: 塞来昔布-NBD
Brand: SIGMA

≥98% (HPLC)

别名:

N-(2-((7-Nitrobenzo[c]-[1,2,5]oxadiazol-4-yl)amino)ethyl)-4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

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关于此项目

经验公式（希尔记法）:

C₂₅H₂₀F₃N₇O₅S

分子量:

587.53

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

protect from light

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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

yellow to orange

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Celecoxib-NBD is a flourescent COX2-specific inhibitor.

Celecoxib-NBD is a flourescent COX2-specific inhibitor. The molecule binds to, and inhibits COX2 with an IC₅₀ of 0.19 μM, and a selectivity index of 443 for COX2 vs. COX1. Celecoxib-NBD fluorescently labels COX2-expressing HCA-7 colon cells, but not COX2-negative HCT116 cells.