SML1074
R1530
≥98% (HPLC)
别名:
5-(2-Chlorophenyl)-7-fluoro-1,2-dihydro-8-methoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine
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关于此项目
经验公式（希尔记法）:
C18H14ClFN4O
化学文摘社编号:
分子量:
356.78
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
color
, white to yellow to light brown
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
ClC1=CC=CC=C1C2=NC3=C(C)NN=C3NC4=C2C=C(F)C(OC)=C4
InChI
1S/C18H14ClFN4O/c1-9-16-18(24-23-9)21-14-8-15(25-2)13(20)7-11(14)17(22-16)10-5-3-4-6-12(10)19/h3-8H,1-2H3,(H2,21,23,24)
InChI key
UOVCGJXDGOGOCZ-UHFFFAOYSA-N
Gene Information
human ... AURKA(6790), FGFR1(2260), FGFR2(2263), FLT1(2321), FLT3(2322), FLT4(2324), KDR(3791), PDGFRB(5159), PLK4(10733)
Biochem/physiol Actions
R1530 is a multi-kinase inhibitor and an anti tumor agent.
R1530 is a multi-kinase inhibitor with activity against several kinases associated with tumor growth and angiogenesis, including VEGFR, FGFR, PDGFR, Chk2 and Cdk2. In tumor cells, R1530 inhibits tubulin polyerization and mitotic checkpoint function, resulting in polyploidy. The compound R1530 inhibits tumor growth and angiogenesis in animal models.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Amreena Suri et al.
International journal of molecular sciences, 20(9) (2019-05-01)
Polo-like kinase 4 (PLK4) is a cell cycle-regulated protein kinase (PK) recruited at the centrosome in dividing cells. Its overexpression triggers centrosome amplification, which is associated with genetic instability and carcinogenesis. In previous work, we established that PLK4 is overexpressed
Tomas Vanek et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 50(11), 1148-1159 (2015-07-21)
Performance of a two-stage biofiltration system was investigated for removal of styrene-acetone mixtures. High steady-state acetone loadings (above C(in)(Ac) = 0.5 g.m(-3) corresponding to the loadings > 34.5 g.m(-3).h(-1)) resulted in a significant inhibition of the system's performance in both
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1074-25MG | 04061832963396 |
| SML1074-5MG | 04061832963402 |