SML1074
R1530
≥98% (HPLC)
别名:
5-(2-Chlorophenyl)-7-fluoro-1,2-dihydro-8-methoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine
并加购，请在购物车里查看协议价、货期和发货地。
选择规格
变更视图
关于此项目
经验公式（希尔记法）:
C18H14ClFN4O
化学文摘社编号:
分子量:
356.78
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
color
, white to yellow to light brown
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
ClC1=CC=CC=C1C2=NC3=C(C)NN=C3NC4=C2C=C(F)C(OC)=C4
InChI
1S/C18H14ClFN4O/c1-9-16-18(24-23-9)21-14-8-15(25-2)13(20)7-11(14)17(22-16)10-5-3-4-6-12(10)19/h3-8H,1-2H3,(H2,21,23,24)
InChI key
UOVCGJXDGOGOCZ-UHFFFAOYSA-N
Gene Information
human ... AURKA(6790), FGFR1(2260), FGFR2(2263), FLT1(2321), FLT3(2322), FLT4(2324), KDR(3791), PDGFRB(5159), PLK4(10733)
Biochem/physiol Actions
R1530 is a multi-kinase inhibitor and an anti tumor agent.
R1530 is a multi-kinase inhibitor with activity against several kinases associated with tumor growth and angiogenesis, including VEGFR, FGFR, PDGFR, Chk2 and Cdk2. In tumor cells, R1530 inhibits tubulin polyerization and mitotic checkpoint function, resulting in polyploidy. The compound R1530 inhibits tumor growth and angiogenesis in animal models.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable