SML1075
Atglistatin 抑制剂
≥98% (HPLC), powder, adipose triglyceride lipase inhibitor
别名:
3-（4′-（二甲氨基）-[1,1′-联苯] -3-基）-1,1-二甲基脲
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C17H21N3O
化学文摘社编号:
分子量:
283.37
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Atglistatin 抑制剂, ≥98% (HPLC)
SMILES string
CN(C)C(NC1=CC=CC(C2=CC=C(N(C)C)C=C2)=C1)=O
InChI
1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)
InChI key
AWOPBSAJHCUSAS-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Application
阿格列汀是一种选择性助理甘油三酯胺酶抑制剂。
Biochem/physiol Actions
Atglistatin 是第一个选择性抑制脂肪甘油三酯脂肪酶 (ATGL) 的药物，ATGL 是参与从细胞甘油三酯储存库动员脂肪酸的限速酶。在大肠埃希菌中，Atglistatin 的IC50为0.7μM，对单甘油脂肪酶（MGL）、激素敏感性脂肪酶（HSL）或胰脂肪酶和脂蛋白脂肪酶PNPLA6和PNPLA7无活性。ATGL从细胞甘油三酸酯储存物中生成二酰基甘油，然后被激素敏感性脂肪酶（HSL）和甘油单酸酯脂肪酶降解为甘油和脂肪酸，从而促进了与胰岛素抵抗发展有关的脂毒性代谢产物的合成。 研究表明，Atglistatin抑制ATGL可减少“体外”和“体内”的脂肪酸动员。
Atglistatin是甘油三酸酯脂肪酶（ATGL）的选择性抑制剂。
Other Notes
产品由格拉茨大学/格拉茨技术大学授权生产。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes.
Hong S, et al.
Molecular Metabolism (2018)
Junichiro Mitsui et al.
The Journal of reproduction and development, 70(2), 72-81 (2024-02-05)
After pregnancy, the corpus luteum (CL) functions as a transient endocrine gland that produces progesterone, which is necessary to maintain pregnancy. To maintain constant progesterone production, CLs are enriched in lipids as its precursors. Lipid droplets (LDs) are organelles that
Xu Xiao et al.
Nature metabolism, 5(1), 165-181 (2023-01-17)
In cell models, changes in the 'accessible' pool of plasma membrane (PM) cholesterol are linked with the regulation of endoplasmic reticulum sterol synthesis and metabolism by the Aster family of nonvesicular transporters; however, the relevance of such nonvesicular transport mechanisms
Kacey J Prentice et al.
Journal of lipid research, 64(6), 100386-100386 (2023-05-13)
Levels of circulating fatty acid binding protein 4 (FABP4) protein are strongly associated with obesity and metabolic disease in both mice and humans, and secretion is stimulated by β-adrenergic stimulation both in vivo and in vitro. Previously, lipolysis-induced FABP4 secretion was found
Xirui Liu et al.
Molecular cancer, 17(1), 90-90 (2018-05-17)
Abnormal metabolism, including abnormal lipid metabolism, is a hallmark of cancer cells. Some studies have demonstrated that the lipogenic pathway might promote the development of hepatocellular carcinoma (HCC). However, the role of the lipolytic pathway in HCC has not been
商品
Discover Bioactive Small Molecules for Lipid Signaling Research
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持