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Merck
CN

SML1078

4-溴白藜芦醇

≥98% (HPLC)

别名:

5-[(1E)-2-(4-溴苯基)乙烯基] -1,3-苯二醇

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关于此项目

经验公式(希尔记法):
C14H11BrO2
化学文摘社编号:
分子量:
291.14
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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产品名称

4-溴白藜芦醇, ≥98% (HPLC)

InChI

1S/C14H11BrO2/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,16-17H/b2-1+

SMILES string

OC1=CC(/C=C/C2=CC=C(Br)C=C2)=CC(O)=C1

InChI key

NCJVLKFAQIWASE-OWOJBTEDSA-N

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

, white to yellow to brown

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

Quality Level

Biochem/physiol Actions

4-溴-白藜芦醇可有效抑制Sirt1和Sirt3。
4-溴-白藜芦醇是一种可有效抑制Sirt1和Sirt3的白藜芦醇类似物。

Features and Benefits

该化合物是基因调控研究推荐产品。点击此处 ,查看更多基因调控精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息,请访问 sigma.com/discover-bsm

General description

4-溴-白藜芦醇可通过与C位点以及另一个活性位点口袋的结合来阻断人sirtuin 1(sirt1)和sirt3的活性。

Other Notes

感光的

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Giang Thi Tuyet Nguyen et al.
Chemistry & biology, 20(11), 1375-1385 (2013-11-12)
Sirtuins are protein deacetylases regulating aging processes and various physiological functions. Resveratrol, a polyphenol found in red wine, activates human Sirt1 and inhibits Sirt3, and it can mimic calorie restriction effects, such as lifespan extension in lower organisms. The mechanism
Mengling Li et al.
Redox biology, 36, 101632-101632 (2020-08-31)
Recent research suggests that melatonin (Mel), an endogenous hormone and natural supplement, possesses anti-proliferative effects and can sensitise cells to anti-cancer therapies. Although shikonin (SHK) also possesses potential anti-cancer properties, the poor solubility and severe systemic toxicity of this compound
Liang-Jun Wang et al.
Biochemical pharmacology, 162, 154-168 (2018-11-11)
Albendazole (ABZ) is a microtubule-targeting anthelmintic that acts against a variety of human cancer cells, but the dependence of its cytotoxicity on non-mitotic effect remains elusive. Thus, we aimed to explore the mechanistic pathway underlying the cytotoxicity of ABZ in

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