BX-912

Name: BX-912
Brand: SIGMA

≥95% (HPLC)

别名:

N-[3-[[5-bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide

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About This Item

经验公式（希尔记法）:

C₂₀H₂₃BrN₈O

CAS Number:

702674-56-4

分子量:

471.35

UNSPSC代码:

12352200

NACRES:

NA.77

质量水平

100

方案

≥95% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

DMSO: 10 mg/mL, clear

储存温度

−20°C

SMILES字符串

Brc1c(nc(nc1)Nc3cc(ccc3)NC(=O)N4CCCC4)NCCc2nc[nH]c2

InChI key

DMMILYKXNCVKOJ-UHFFFAOYSA-N

生化/生理作用

BX-912 is a potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1). The IC50 values for direct inhibition of kinase activity or inhibition in a cell based assay are 26 nM and 12 nM, respectively. BX-912 inhibits the growth of PC-3 tumor cells grown on soft agar more potently than cells grown on plastic (IC50 = 320 nM vs. 5.5 mM, respectively).

PDK1 inhibitor