SML1116
PQ-10
≥98% (HPLC)
别名:
6,7-Dimethoxy-4-[(3R)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]-quinazoline, PQ 10
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关于此项目
经验公式（希尔记法）:
C22H21N5O3
化学文摘社编号:
分子量:
403.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
COC1=CC2=C(N3C[C@H](OC4=CN=C(C=CC=C5)C5=N4)CC3)N=CN=C2C=C1OC
InChI
1S/C22H21N5O3/c1-28-19-9-15-18(10-20(19)29-2)24-13-25-22(15)27-8-7-14(12-27)30-21-11-23-16-5-3-4-6-17(16)26-21/h3-6,9-11,13-14H,7-8,12H2,1-2H3/t14-/m1/s1
InChI key
UBIIFKJMNRPNMT-CQSZACIVSA-N
Biochem/physiol Actions
PQ-10 (6,7-dimethoxy-4-[3-(quinoxalin-2-yloxy)pyrrolidin-1-yl]quinazoline), is capable of suppressing tumor cell growth. It can also reverse the RO-4-1284-induced sedation and catalepsy.
PQ-10 is a potent and selective inhibitor of phosphodiesterase 10A (PDE10).
PQ-10 is a potent and selective inhibitor of phosphodiesterase 10A (PDE10). Apparently, PQ-10 enhances basic auditory information processing in rats. PQ-10 as other PED10 inhibitors suppresses a growth of human non-small cell lung cancer (NSCLC) cell lines.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
PDE 10A inhibitors stimulate or suppress motor behavior dependent on the relative activation state of the direct and indirect striatal output pathways
Megens AAHP, et al.
Pharmacology Research & Perspectives, 2(4), e00057-e00057 (2014)
Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and beta-catenin-dependent TCF transcriptional activity
Li N, et al.
Oncogene, 34(12), 1499-1499 (2015)
Quality of life and non-motor symptoms in Parkinson's disease patients with subthreshold depression.
D Santos-García et al.
Journal of the neurological sciences, 418, 117109-117109 (2020-09-15)
The role of subthreshold depression (subD) in Parkinson's Disease (PD) is not clear. The present study aimed to compare the quality of life (QoL) in PD patients with subD vs patients with no depressive disorder (nonD). Factors related to subD
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1116-25MG | 04061832900261 |
| SML1116-5MG | 04061837107610 |