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SML1117

ML345

Name: ML345
Brand: SIGMA

≥98% (HPLC)

别名:

5-Fluoro-2-[5-(morpholine-4-sulfonyl)-2-morpholin-4-yl-phenyl]-benzo[d]isothiazol-3-one, CID 57390068

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关于此项目

经验公式（希尔记法）:

C₂₁H₂₂FN₃O₅S₂

化学文摘社编号:

1632125-79-1

分子量:

479.54

UNSPSC Code:

51111800

PubChem Substance ID:

329825658

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

O=S(C1=CC(N(C2=O)SC3=C2C=C(F)C=C3)=C(N4CCOCC4)C=C1)(N5CCOCC5)=O

InChI

1S/C21H22FN3O5S2/c22-15-1-4-20-17(13-15)21(26)25(31-20)19-14-16(32(27,28)24-7-11-30-12-8-24)2-3-18(19)23-5-9-29-10-6-23/h1-4,13-14H,5-12H2

InChI key

FVKOFZKSMMIUTL-UHFFFAOYSA-N

说明

Biochem/physiol Actions

ML345 has effective concentration (EC50) value of 188 nM.

ML345 is a cell penetrant, potent and moderately selective insulin degrading enzyme (IDE) inhibitor that targets Cys819 in IDE. IDE is involved in β-chain of insulin degradation and linked to β-amyloid degradation. Recent findings indicate that IDE inhibition is a valid strategy for diabetes mellitus type 2 (DMT2) treatment.

ML345 is a cell penetrant, potent and moderately selective insulin degrading enzyme (IDE) inhibitor.