SML1165

他尔奈坦

Name: 他尔奈坦
Brand: SIGMA

≥98% (HPLC)

别名:

(S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide, SB-223412

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关于此项目

经验公式（希尔记法）:

C₂₅H₂₂N₂O₂

化学文摘社编号:

174636-32-9

分子量:

382.45

NACRES:

NA.77

PubChem Substance ID:

329825695

UNSPSC Code:

12352200

MDL number:

MFCD00944075

主要文件

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产品名称

他尔奈坦, ≥98% (HPLC)

InChI

1S/C25H22N2O2/c1-2-20(17-11-5-3-6-12-17)27-25(29)22-19-15-9-10-16-21(19)26-23(24(22)28)18-13-7-4-8-14-18/h3-16,20,28H,2H2,1H3,(H,27,29)/t20-/m0/s1

SMILES string

OC(C(C(N[C@H](C1=CC=CC=C1)CC)=O)=C(C=CC=C2)C2=N3)=C3C4=CC=CC=C4

InChI key

BIAVGWDGIJKWRM-FQEVSTJZSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -25 to -31°, c = 0.5 in methanol

color

white to beige

solubility

DMSO: 25 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... TACR3(6870)

Biochem/physiol Actions

Talnetant (SB-223,412) is a highly selective antagonist of neurokinin 3 receptor with a Ki (NK3) = 1 nM >10000 (NK1) >140 (NK2). Neurokinins (tachykinins) are members of a family of at least three neuropeptides, substance P, neurokinin A, and neurokinin B (NKB), with each mediating their biological effects through binding to a preferred G-protein-coupled receptor termed NK1, NK2, or NK3, respectively. All three NK receptors are expressed in regions of the central nervous system that are related to emotion and cognition (i.e., amygdala and hippocampus) and have been linked to various degrees in psychiatric disorders. Neurokinin receptors, including NK3 receptors, are also expressed in the motor and sensory systems of the digestive tract. Talnetant was in clinical trials for both irritable bowel syndrome and schizophrenia.

Talnetant is a highly selective antagonist of neurokinin 3 receptor.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.