SML1186
GGTI-286 二盐酸盐
≥90% (HPLC)
别名:
(R)-N-[[5-[(2-Amino-3-mercaptopropyl)amino][1,1′-biphenyl]-2-yl]carbonyl]-L-lLeucine methyl ester dihydrochloride, GGTI 286 dihydrochloride, N-[[5-[[(2R)-2-Amino-3-mercaptopropyl]amino][1,1′-biphenyl]-2-yl]carbonyl]-L-leucine methyl ester dihydrochloride
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关于此项目
Assay:
≥90% (HPLC)
Form:
powder
Storage condition:
desiccated
assay
≥90% (HPLC)
form
powder
storage condition
desiccated
color
white to light brown
solubility
DMSO: 20 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
SMILES string
SC[C@H](N)CNc1cc(c(cc1)C(=O)N[C@@H](CC(C)C)C(=O)OC)c2ccccc2
InChI key
IENQPUVVSDIXCT-UTKZUKDTSA-N
Biochem/physiol Actions
GGTI-286 is a cell permeable, potent and selective inhibitor of geranylgeranyltransferase I (GGTase I) that selectively disrupts oncogenic K-Ras4B. New study shows that GGTI-286 reduces nuclear localization of β-catenin.
GGTI-286 is a cell permeable, potent and selective inhibitor of geranylgeranyltransferase I (GGTase I). CAAX peptidomimetic.
Other Notes
Air sensitive; dessicant.
警示词
Warning
危险代码
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable