SML1188
PYZD-4409
≥98% (HPLC)
别名:
1-(3-Chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione
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关于此项目
经验公式（希尔记法）:
C14H7ClFN3O5
化学文摘社编号:
分子量:
351.67
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C14H7ClFN3O5/c15-10-5-7(1-3-11(10)16)18-14(21)9(13(20)17-18)6-8-2-4-12(24-8)19(22)23/h1-6H,(H,17,20)
SMILES string
FC1=CC=C(N2C(C(C(N2)=O)=CC3=CC=C([N+]([O-])=O)O3)=O)C=C1Cl
InChI key
MSYMKEYWUWVZQY-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
, white to very dark brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
PYZD-4409 inhibts ATP-dependent activation of human ubiquitin activating enzyme E1 with an IC50 of 20 mM. PYZD-4409 induces cell death, and inhbits clonogenic growth of leukemia and myeloma cell lines, and inhibits leukemia xenograft tumor growth in mice.
PYZD-4409 inhibts ATP-dependent activation of human ubiquitin activating enzyme E1.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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