SML1189
4-P-PDOT
≥98% (HPLC)
别名:
4-苯基-2-丙酰氨基四氢化萘, 4P-PDOT, AH 024, N-(1,2,3,4-四氢-4-苯基-2-萘基)-丙酰胺, 顺式-4-苯基-2-丙酰氨基四氢化萘
产品名称
4-P-PDOT, ≥98% (HPLC)
SMILES string
N(C1CC(c3c(cccc3)C1)c2ccccc2)C(=O)CC
InChI
1S/C19H21NO/c1-2-19(21)20-16-12-15-10-6-7-11-17(15)18(13-16)14-8-4-3-5-9-14/h3-11,16,18H,2,12-13H2,1H3,(H,20,21)
InChI key
RCYLUNPFECYGDW-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
room temp
Quality Level
Biochem/physiol Actions
4-P-PDOT是一种选择性MT2褪黑激素受体拮抗剂。
4-P-PDOT是一种选择性MT2褪黑激素受体拮抗剂，它对MT2 (MEL-1B-R)的选择性是MT1（MEL-1A-R）褪黑激素受体亚型的300倍。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Granulosa cells play an essential physiological role in mediating the follicle development and survival or apoptosis of granulosa cells dictate the follicle development or atresia. The aim of this study was to investigate the role of high dose (10-5 M)
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Retarded wound healing in patients with obesity contributes to a risk of complications associated with vascular insufficiency and oxidative stress. The high cholesterol levels of patients with obesity are associated with apoptosis of engrafted umbilical cord blood-derived mesenchymal stem cells
Jing-Li Tao et al.
Antioxidants (Basel, Switzerland), 10(2) (2021-02-03)
In mammalian ovaries, the avascular environment within follicular cavity is supposed to cause hypoxic status in granulosa cells (GCs), leading to apoptotic cell death accompanied by cumulative reactive oxygen species (ROS) production. Melatonin (N-acetyl-5-methoxytryptamine, MT), a broad-spectrum antioxidant that exists
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Autophagy, 14(11), 1850-1869 (2018-07-10)
To explore the anti-inflammatory activity of endogenous produced melatonin, a melatonin-enriched animal model (goat) with AANAT transfer was successfully generated with somatic cell nuclear transfer (SCNT) technology. Basically, a pIRES2-EGFP-AANAT expression vector was constructed and was transferred into the female
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