SML1195
Palonosetron 盐酸盐
≥98% (HPLC)
别名:
(3aS)-2-[(3S)-奎宁环丁-3-基] -2,3,3a，4,5,6-六氢--1H-苯并[de]异喹啉-1-酮 盐酸盐, (3aS)-2-[(3S)-1-氮杂双环[2.2.2] 辛-3-基] -2,3,3a,4,5,6-六氢-1H-苯并[异]喹啉-1-酮 盐酸盐(1：1), RS 25259-197
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关于此项目
经验公式（希尔记法）:
C19H24N2O · HCl
化学文摘社编号:
分子量:
332.87
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/m1./s1
SMILES string
O=C1N([C@H]2C3CCN(CC3)C2)C[C@]4([H])C5=C1C=CC=C5CCC4.[H]Cl
InChI key
OLDRWYVIKMSFFB-SSPJITILSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -90 to -110°, c = 0.4 in H2O
storage condition
desiccated, protect from light
color
white to beige
solubility
H2O: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
Gene Information
human ... HTR3A(3359)
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Biochem/physiol Actions
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帕洛诺司琼是一种有效且选择性的5-HT3受体拮抗剂（Aloxi），可用于预防和治疗化学疗法诱发的恶心和呕吐（CINV）。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Jing Ma et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(12), 13560-13571 (2019-10-02)
So far, a comprehensive animal model that can mimic both the central and peripheral pathophysiological changes of irritable bowel syndrome (IBS) is lacking. Here, we developed a novel IBS rat model combining trinitro-benzene-sulfonic acid (TNBS) and chronic unpredictable mild stress
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