产品名称
Torin2, ≥98% (HPLC)
SMILES string
FC(F)(F)c1cc(ccc1)[n]2c3c4c(ncc3cc[c]2=O)ccc(c4)c5cnc(cc5)N
InChI
1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)
InChI key
GUXXEUUYCAYESJ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Application
Torin2已被用于:
- 检查其对BORCS5-KO细胞中LC3B-II水平的影响
- 确定其对A2780-顺式卵巢癌细胞的有效活性(IC50小于1 μM)
- 蛋白质印迹分析
Biochem/physiol Actions
Torin2是一种高效且具有选择性的ATP竞争性mTOR抑制剂。
Torin2是一种高效且具有选择性的ATP竞争性mTOR抑制剂。Torin2的IC50为0.25 nM,与PI3K相比,它对mTOR的选择性高800倍。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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