SML1277
Geldanamycin-FITC
≥98% (HPLC), from Streptomyces hygroscopicus
别名:
Geldanamycin, fluorescein isothiocyanate labeled
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关于此项目
经验公式（希尔记法）:
C55H63N5O13S
分子量:
1034.18
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
protect from light
biological source
Streptomyces hygroscopicus
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
yellow to yellow-orange
solubility
DMSO: soluble 5 mg/mL
antibiotic activity spectrum
neoplastics
mode of action
enzyme | inhibits
storage temp.
−20°C
General description
Chemical structure: benzenoid
Biochem/physiol Actions
Geldanamycin-FITC is a fluorescent derivative of geldanamycin. It is used as a fluorescent tracer for heat shock protein 90 (HSP90) inhibitors in fluorescence polarization (FP) competition binding assay.
Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.
Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable