SML1278
Geldanamycin Ready Made Solution
1 mg/mL, from Streptomyces hygroscopicus
别名:
2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate (8CI)
SMILES string
N1C2=CC(=O)C(=C(C[C@H](C[C@@H]([C@@H]([C@H](\C=C(\[C@@H]([C@H](\C=C/C=C(/C1=O)\C)OC)OC(=O)N)/C)C)O)OC)C)C2=O)OC
InChI
1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
InChI key
QTQAWLPCGQOSGP-KSRBKZBZSA-N
biological source
Streptomyces hygroscopicus
form
DMSO solution
storage condition
protect from light
concentration
1 mg/mL
antibiotic activity spectrum
neoplastics
mode of action
enzyme | inhibits
shipped in
dry ice
storage temp.
−20°C
Quality Level
General description
Chemical structure: benzenoid
Application
Geldanamycin Ready-Made Solution has been used as a heat shock protein 90 (Hsp90) inhibitor to pre-treat proteosome holo-enzyme during proteasome assay to study the role of proteasome on fibril fragmentation.
Biochem/physiol Actions
Geldanamycin is a benzoquinone ansamycin and is a well known tyrosine kinase inhibitor. It possesses anticancer effects and shows therapeutic effects against osteosarcoma.
Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.
Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F
flash_point_c
87 °C
法规信息
新产品
此项目有
Magdalena Gorska et al.
PloS one, 8(8), e71135-e71135 (2013-09-10)
Osteosarcoma is one of the most malignant tumors of childhood and adolescence that is often resistant to standard chemo- and radio-therapy. Geldanamycin and geldanamycin analogs have been recently studied as potential anticancer agents for osteosarcoma treatment. Here, for the first
Rachel Cliffe et al.
Cell reports, 26(8), 2140-2149 (2019-02-21)
Filamentous aggregates (fibrils) are regarded as the final stage in the assembly of amyloidogenic proteins and are formed in many neurodegenerative diseases. Accumulation of aggregates occurs as a result of an imbalance between their formation and removal. Here we use
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