SML1285
非布索坦
98.5-102.0% (dry basis), powder, xanthine oxidase inhibitor
别名:
2-(3-氰基-4-异丁氧基苯基)-4-甲基-1,3-噻唑-5-羧酸, Adenuric, Atenuri, Uloric
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关于此项目
经验公式（希尔记法）:
C16H16N2O3S
化学文摘社编号:
分子量:
316.37
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
非布索坦, 98.5-102.0%
Quality Level
assay
98.5-102.0%
form
powder
storage temp.
2-8°C
SMILES string
CC(C)COC1=C(C#N)C=C(C2=NC(C)=C(C(O)=O)S2)C=C1
InChI
1S/C16H16N2O3S/c1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14(22-15)16(19)20/h4-6,9H,8H2,1-3H3,(H,19,20)
InChI key
BQSJTQLCZDPROO-UHFFFAOYSA-N
General description
非布索坦是一种强效的非嘌呤化合物，可抑制细胞因子/趋化因子的表达。还有研究报道称，它能够抑制LPS诱导的TNF-α、VCAM-1、MMP9和MCP-1表达。
Biochem/physiol Actions
非布索坦是一种有效的非嘌呤类的黄嘌呤氧化酶抑制剂。
非布索坦是一种有效的非嘌呤类的黄嘌呤氧化酶抑制剂。非布索坦被用于尿酸降低疗法（ULT）以治疗痛风。
Disclaimer
易溶于N,N-二甲基甲酰胺，可溶于二甲基亚砜，略溶于乙醇或三氯甲烷，微溶于甲醇，几乎不溶于水。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Johji Nomura et al.
PloS one, 8(9), e75527-e75527 (2013-10-03)
Excess reactive oxygen species (ROS) formation can trigger various pathological conditions such as inflammation, in which xanthine oxidase (XO) is one major enzymatic source of ROS. Although XO has been reported to play essential roles in inflammatory conditions, the molecular
Yoshiro Tanaka et al.
Free radical biology & medicine, 162, 298-308 (2021-01-21)
Accumulating evidence suggests that high serum uric acid (UA) is associated with left ventricular (LV) dysfunction. Although xanthine oxidase (XO) activation is a critical regulatory mechanism of the terminal step in ATP and purine degradation, the pathophysiological role of cardiac
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1285-1G | 04061838356949 |