SML1297
SB269652
≥98% (HPLC)
别名:
N-[trans-4-[2-(7-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-1H-indole-2-carboxamide
产品名称
SB269652, ≥98% (HPLC)
SMILES string
[nH]1c2c(cc1C(=O)N[C@@H]3CC[C@H](CC3)CCN4CCc5c(cc(cc5)C#N)C4)cccc2
InChI
1S/C27H30N4O/c28-17-20-5-8-21-12-14-31(18-23(21)15-20)13-11-19-6-9-24(10-7-19)29-27(32)26-16-22-3-1-2-4-25(22)30-26/h1-5,8,15-16,19,24,30H,6-7,9-14,18H2,(H,29,32)/t19-,24-
InChI key
JGLGOAQPUQITLD-OGAOHHHESA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Allosteric modulator of D2 dopamine receptors
SB269652 is an allosteric modulator of D2 dopamine receptors. SB269652 binds to an allosteric site that is distinct from the orthosteric bound by typical D2 antagonists and is only revealed in D2 receptor dimers. SB269652 is bitopic, binding to an orthosteric site one one partner in the dimer and the allosteric site in the other. Engagement of this secondary pocket at the extracellular end of TM2 and TM7 is a new mechanism of modulating binding of a ligand to the orthosteric site of a second protomer by a G-protein coupled receptor.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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