SML1313
BMS 204352
≥98% (HPLC)
别名:
（3S）-（+）-（5-氯-2-甲氧基苯基）-1,3-二氢-3-氟-6-（三氟甲基）-2H-吲哚-2-酮
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关于此项目
经验公式（希尔记法）:
C16H10ClF4NO2
化学文摘社编号:
分子量:
359.70
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
BMS 204352, ≥98% (HPLC)
InChI
1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
SMILES string
O=C1NC2=CC(C(F)(F)F)=CC=C2[C@@]1(C3=CC(Cl)=CC=C3OC)F
InChI key
ULYONBAOIMCNEH-HNNXBMFYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
Gene Information
human ... KCNMA1(3778), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479)
Application
BMS 204352已被用于药物管理中。
Biochem/physiol Actions
BMS 204352是一种钾离子通道调节剂。
BMS 204352是一种钾离子通道调节剂。BMS 204352最初是作为大电导体，钙激活（Maxi-K，KCa1.1，BK）钾离子通道，的有效开启剂，其也可充当Kv7（KCNQ）通道的正调节剂。
BMS 204352（MaxiPost [（3S）-（+）-（5-氯-2-甲氧基苯基）-1,3-二氢-3-氟-6-（三氟甲基）-2H-吲哚-2-酮）]已被用于治疗缺血性中风。它也可以相同的效力充当KNCQ4（类KQT的亚家族，成员4）和KCNQ5（类KQT的亚家族，成员5）的激活剂。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Mohammad Al-Mahdi Al-Karagholi et al.
Cephalalgia : an international journal of headache, 40(11), 1145-1154 (2020-08-28)
Preclinical data implicate large conductance calcium-activated potassium (BKCa) channels in the pathogenesis of headache and migraine, but the exact role of these channels is still unknown. Here, we investigated whether opening of BKCa channels would cause headache and vascular effects
Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule.
Hebert B, et al.
Orphanet Journal of Rare Diseases, 9(1), 124-124 (2014)
METABOLISM, PHARMACOKINETICS, AND PROTEIN COVALENT BINDING OF RADIOLABELED MAXIPOST IN HUMANS.
Zhang D, et al.
Drug Metabolism and Disposition, 33(1), 83-93 (2004)
A small molecule activator of KCNQ2 and KCNQ4 channels.
Probe Reports from the NIH Molecular Libraries Program (2013)
CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory.
Song T, et al.
PLoS Genetics, 14(1), e1007165-e1007165 (2018)
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