SML1315

雷尼司他

Name: 雷尼司他
Brand: SIGMA

≥97% (HPLC)

别名:

(3R)-2′-[(4-Bromo-2-fluorophenyl)methyl]-spiro[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-a]pyrazine]-1′,2,3′,5(2′H)-tetrone., AS-3201

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₁BrFN₃O₄

化学文摘社编号:

147254-64-6

分子量:

420.19

NACRES:

NA.77

PubChem Substance ID:

329825780

UNSPSC Code:

12352200

MDL number:

MFCD00920915

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产品名称

雷尼司他, ≥97% (HPLC)

InChI key

QCVNMNYRNIMDKV-QGZVFWFLSA-N

SMILES string

O=C(N1CC2=C(F)C=C(Br)C=C2)C3=CC=CN3[C@@]4(CC(NC4=O)=O)C1=O

InChI

1S/C17H11BrFN3O4/c18-10-4-3-9(11(19)6-10)8-21-14(24)12-2-1-5-22(12)17(16(21)26)7-13(23)20-15(17)25/h1-6H,7-8H2,(H,20,23,25)/t17-/m1/s1

assay

≥97% (HPLC)

form

powder

optical activity

[α]/D -5 to -10°, c = 1.0 in methanol

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Ranirestat (AS-3201) is an aldose reductase (AR) inhibitor.

Ranirestat (AS-3201) is an aldose reductase (AR) inhibitor. Aldose reductase is a rate-limiting enzyme in the conversion of D-glucose to fructose via D-sorbitol. Ranirestat has been implicated in diabetic complications (cataract formation, retinopathy, neuropathy, nephropathy). Ranirestat prevents sorbitol accumulation and is thus hoped to be effective in the remedy of diabetic neuropathy.