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Merck
CN

SML1325

Sigma-Aldrich

HS-72

≥98% (HPLC)

别名:

(S)-N-(1-propyl-1H-benzimidazol-2-yl)-1-(2-pyrazinyl)-3-Piperidinecarboxamide

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关于此项目

经验公式(希尔记法):
C20H24N6O
分子量:
364.44
UNSPSC代码:
12352200
NACRES:
NA.77
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质量水平

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

2-8°C

生化/生理作用

HS-72 is a cell permeable, highly selective allosteric inhibitor of inducible Hsp70 (Hsp70i) over constitutively active Hsc70. HS-72 inhibits cancer cell proliferation and promotes a survival in a HER2+ mouse model of breast cancer.
HS-72 is a cell permeable, highly selective allosteric inhibitor of inducible Hsp70 (Hsp70i).
HS-72 is also termed as ((S)-N-(1-propyl-1H-benzo[d]imidazol-2-yl)-1-(pyrazin-2-yl)piperidine-3-carboxamide). It is considered as a powerful anti-dengue virus (DENV) therapeutic agent. It displays anti-DENV activity in monocyte and liver cell lines. HS-72 stimulates the accumulation of cellular proteins.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Matthew K Howe et al.
Chemistry & biology, 21(12), 1648-1659 (2014-12-17)
Inducible Hsp70 (Hsp70i) is overexpressed in a wide spectrum of human tumors, and its expression correlates with metastasis, poor outcomes, and resistance to chemotherapy in patients. Identification of small-molecule inhibitors selective for Hsp70i could provide new therapeutic tools for cancer
An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target
Howe M K, et al.
Antiviral Research, 130, 81-92 (2016)

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