SML1337
NQ301
≥98% (HPLC)
别名:
2-Chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone, 2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione, Compound 211, NQ 301
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关于此项目
经验公式（希尔记法）:
C23H19N3O · HBr
化学文摘社编号:
分子量:
434.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
, faint red to dark red
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O
InChI
1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3
InChI key
LSQZKIQSQHZVQS-UHFFFAOYSA-N
Biochem/physiol Actions
NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice.
NQ301 is an antithrombotic agent; antiplatelet; highly potent, selective non-competitive allosteric inhibitor of CD45.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable