SML1353
ML351
≥98% (HPLC)
别名:
5-（甲基氨基）-2-（1-萘基）-4-恶唑腈, CID 664510, ML 351, SID 104223766
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选择尺寸
关于此项目
经验公式（希尔记法）:
C15H11N3O
化学文摘社编号:
分子量:
249.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
ML351, ≥98% (HPLC)
InChI
1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3
SMILES string
CNC1=C(C#N)N=C(O1)C2=C3C(C=CC=C3)=CC=C2
InChI key
DYXYXTDIFMDJIR-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
ML351 是一种细胞可透过性、选择性和有效的人脂氧合酶 12/15（15-脂氧合酶-1，12/15-LOX）抑制剂，在小鼠神经元 HT22 细胞中具有对氧化谷氨酸毒性的保护作用。 ML351 减少了缺血性中风的小鼠模型中的梗死面积。
ML351 是一种细胞可透过性、选择性和有效的人脂氧合酶-12/15（15-脂氧合酶-1，12/15-LOX）抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Sally E Wenzel et al.
Cell, 171(3), 628-641 (2017-10-21)
Ferroptosis is a form of programmed cell death that is pathogenic to several acute and chronic diseases and executed via oxygenation of polyunsaturated phosphatidylethanolamines (PE) by 15-lipoxygenases (15-LO) that normally use free polyunsaturated fatty acids as substrates. Mechanisms of the
Lisa Mayr et al.
Nature communications, 11(1), 1775-1775 (2020-04-15)
The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption of a Western life-style. Westernization of dietary habits is partly characterized by enrichment with the ω-6 polyunsaturated fatty acid (PUFA) arachidonic
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