SML1366
CVT-10216
≥98% (HPLC)
别名:
3-[[[[3- [4-[（甲基磺酰基）氨基]苯基] -4-氧代-4H-1-苯并吡喃-7-基]氧基]甲基]-苯甲酸, 3-[[[[3- [4-[（甲基磺酰基）氨基]苯基] -4-氧代-4H-铬基-7-基]氧基]甲基]苯甲酸, CVT 10216, GS 455534
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选择尺寸
关于此项目
经验公式（希尔记法）:
C24H19NO7S
化学文摘社编号:
分子量:
465.48
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
CVT-10216, ≥98% (HPLC)
InChI
1S/C24H19NO7S/c1-33(29,30)25-18-7-5-16(6-8-18)21-14-32-22-12-19(9-10-20(22)23(21)26)31-13-15-3-2-4-17(11-15)24(27)28/h2-12,14,25H,13H2,1H3,(H,27,28)
SMILES string
O=C(O)C1=CC(COC2=CC=C3C(OC=C(C4=CC=C(NS(C)(=O)=O)C=C4)C3=O)=C2)=CC=C1
InChI key
YYOOFJZTRCPVFD-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
CVT-10216 是乙醛脱氢酶 2 的选择性可逆抑制剂。
CVT-10216 具有明确的抗焦虑特性。它不影响 mCPP（间氯苯基哌嗪）对运动活性的抑制。
CVT-10216 是乙醛脱氢酶 2（ALDH-2）的选择性可逆抑制剂，从而抑制多巴胺的合成。CVT-10216 可有效抑制酒精和可卡因的使用以及焦虑症。
General description
CVT-10216 是 5-Ht2c 激动剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
David H Overstreet et al.
Pharmacology, biochemistry, and behavior, 94(2), 255-261 (2009-09-15)
CVT-10216 is a highly selective, reversible inhibitor of ALDH-2 that reduces excessive alcohol drinking. Anxiety plays a role in alcoholism. The present study asks whether CVT-10216 has anxiolytic properties, as reflected in social interaction behavior in four unrelated rodent models:
Bin Yuan et al.
PloS one, 15(11), e0242809-e0242809 (2020-12-01)
The bone marrow microenvironment (BME) in acute myeloid leukemia (AML) consists of various cell types that support the growth of AML cells and protect them from chemotherapy. Mesenchymal stromal cells (MSCs) in the BME have been shown to contribute immensely
Simin Zhang et al.
Aesthetic plastic surgery, 44(3), 993-1005 (2020-01-19)
The cutaneous wound healing process mainly comprises re-epithelialization, fibrosis, and neovascularization. Impaired wound healing is common but tricky in plastic surgery. Aldehyde dehydrogenase 2 (ALDH2), the most effective subset of the ALDH enzyme family, is known to exert a major
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