SML1377
R-7050
≥95% (HPLC)
别名:
8-Chloro-4-(phenylsulfanyl)-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxaline, 8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
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关于此项目
经验公式（希尔记法）:
C16H8ClF3N4S
化学文摘社编号:
分子量:
380.77
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Quality Level
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
shipped in
wet ice
storage temp.
−20°C
SMILES string
ClC1=CC=C(N=C(SC2=CC=CC=C2)C3=NN=C(C(F)(F)F)N34)C4=C1
InChI
1S/C16H8ClF3N4S/c17-9-6-7-11-12(8-9)24-13(22-23-15(24)16(18,19)20)14(21-11)25-10-4-2-1-3-5-10/h1-8H
InChI key
SUUMKHOVGVYGOP-UHFFFAOYSA-N
Biochem/physiol Actions
R-7050 is a cell-permeable TNF-α receptor antagonist that blocks TNF-α-induced binding of TNF-αRI with TNFαR-associated death domain protein and receptor interacting protein 1, blocking internalization of the TNFα-TNFαR complex. R-7050 was found to reduce neurovascular injury in a mouse model of hemorrhagic stroke.
R-7050 is a cell-permeable TNF-α receptor antagonist.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Thomas Mudersbach et al.
PloS one, 14(5), e0216218-e0216218 (2019-05-03)
The angiotensin-converting enzyme (ACE) plays a central role in the renin-angiotensin system, which is involved in the regulation of blood pressure. Alterations in ACE expression or activity are associated with various pathological phenotypes, particularly cardiovascular diseases. In human endothelial cells
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1377-5MG | 04061833225875 |
| SML1377-25MG | 04061833225868 |