SML1383
OG-L002 hydrochloride
≥98% (HPLC)
别名:
4′-((1R,2S)-2-Aminocyclopropyl)-[1,1′-biphenyl]-3-ol hydrochloride
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关于此项目
经验公式（希尔记法）:
C15H15NO · HCl
化学文摘社编号:
分子量:
261.75
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
, light yellow to dark orange
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
N[C@@H]1[C@@H](C(C=C2)=CC=C2C3=CC=CC(O)=C3)C1.Cl
InChI
1S/C15H15NO.ClH/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12;/h1-8,14-15,17H,9,16H2;1H/t14-,15+;/m1./s1
InChI key
LPVCAMIPTMRRLZ-LIOBNPLQSA-N
相关类别
生化/生理作用
OG-L002 is a recently developed inhibitor of LSD1.
OG-L002 is a recently developed inhibitor with IC50 of 20 nM at LSD1 and much lower activity at MAO-A and MAO-B (1.38 and 0.72 μM, respectively). OG-L002 exhibits potent anti-viral activity in vitro and in mouse models of HSV infection. Lysine specific demethylase 1 (LSD1) is a histone demethylase that removes methyl groups from lysine 4 or 9 of H3 histone tails. Inhibition of LSD1 leds to suppression of herpes simplex and herpes zoster viral infections and viral reactivation from latency. MAO inhibitors (pargyline, tranylcypromine) are known to inhibit LSD1, but with low potency and selectivity. OG-L002 is a more selective and potent tool for LSD1 inhibition.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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