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SML1385

Lomitapide

Name: Lomitapide
Brand: SIGMA

≥98% (HPLC), microsomal triglyceride transfer protein (MTP) inhibitor, powder

别名:

AEGR-733, BMS-201038, N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]2-yl]carbonyl]amino]-1-piperidinyl]butyl]9H-fluoren-9-carboxamde

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关于此项目

经验公式（希尔记法）:

C₃₉H₃₇F₆N₃O₂

化学文摘社编号:

182431-12-5

分子量:

693.72

UNSPSC Code:

51111800

PubChem Substance ID:

329825833

NACRES:

NA.77

MDL number:

MFCD16620494

Assay:

≥98% (HPLC)

Form:

powder

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属性

产品名称

Lomitapide, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NCC(F)(F)F)C1(C(C=CC=C2)=C2C3=C1C=CC=C3)CCCCN(CC4)CCC4NC(C5=C(C6=CC=C(C(F)(F)F)C=C6)C=CC=C5)=O

InChI

1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)

InChI key

MBBCVAKAJPKAKM-UHFFFAOYSA-N

Gene Information

human ... MTTP(4547), P4HB(5034)

说明

Application

Lomitapide has been used as a microsomal triglyceride transfer protein (MTP) inhibitor to study its effects on very-low-density lipoproteins (VLDL) export in mouse hepatocytes.

Biochem/physiol Actions

Lomitapide can lower the secretion of very-low-density lipoproteins (VLDL) and chylomicrons.

Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).

Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP). Lomitapide has been shown to be highly effective in reducing LDL-cholesterol and triglycerides, and has been aproved for treatment of homozygous familial hypercholesterolemia.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000418770

0000418771

0000413587