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SML1391

Olmesartan medoxomil

Name: Olmesartan medoxomil
Brand: SIGMA

≥98% (HPLC), Angiotensin II Type I receptor blocker, powder

别名:

4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester, CS-866

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关于此项目

经验公式（希尔记法）:

C₂₉H₃₀N₆O₆

化学文摘社编号:

144689-63-4

分子量:

558.59

UNSPSC Code:

12352200

PubChem Substance ID:

329825839

NACRES:

NA.77

MDL number:

MFCD00944911

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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产品名称

Olmesartan medoxomil, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CCCC1=NC(C(O)(C)C)=C(C(OCC2=C(C)OC(O2)=O)=O)N1CC(C=C3)=CC=C3C4=CC=CC=C4C5=NN=NN5

InChI

1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34)

InChI key

UQGKUQLKSCSZGY-UHFFFAOYSA-N

Gene Information

human ... AGTR1(185)

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Biochem/physiol Actions

Olmesartan medoxomil is considered as an antihypertensive agent. It is an angiotensin 2 type 1 antagonist receptor. It is a prodrug which releases the parent compound olmesartan after ingestion. Olmesartan is ejected via kidney and liver. In humans, olmesartan protects renal and cardiovascular systems. This drug may be used in the treatment of hypertension.

Olmesartan medoxomil is a selective Angiotensin II Type I receptor blocker and antihypertensive drug. Olmesartan medoxomil is converted enzymatically to the active form olmesartan.

pictograms

GHS07

signalword

Warning

hcodes

H302 + H312 + H332

pcodes

P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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The new oral angiotensin II antagonist olmesartan medoxomil: a concise overview.

Hans R Brunner

Journal of human hypertension, 16 Suppl 2, S13-S16 (2002-04-23)

The new orally active angiotensin II (A II) type-1 receptor antagonist olmesartan medoxomil is a prodrug, which is rapidly converted in vivo to the active metabolite, olmesartan. The pharmacology, antihypertensive efficacy and safety of olmesartan medoxomil and/or the pharmacologically active

Case Studies in Modern Drug Discovery and Development (2012)

Current Cardiovascular Drugs (2005)

Angiotensin II Inhibitors: Advances in Research and Application (2012)

Linear mixed-effects model of QTc prolongation for olmesartan medoxomil.

SaeHeum Song et al.

Journal of clinical pharmacology, 56(1), 96-100 (2015-06-23)

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全球贸易项目编号

货号	GTIN
SML1391-250MG	04061832900476
SML1391-50MG	04061832900483

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