SML1392
FDI-6
≥98% (HPLC)
别名:
3-氨基-N-（4-氟苯基）-6-（2-噻吩基）-4-（三氟甲基）-噻吩并[2,3-b]吡啶-2-羧酰胺, 3-氨基-N-（4-氟苯基）-6-（噻吩-2-基）-4-（三氟甲基）噻吩并[2,3-b]吡啶-2-羧酰胺, NCGC00099374
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关于此项目
经验公式（希尔记法）:
C19H11F4N3OS2
化学文摘社编号:
分子量:
437.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
FDI-6, ≥98% (HPLC)
InChI
1S/C19H11F4N3OS2/c20-9-3-5-10(6-4-9)25-17(27)16-15(24)14-11(19(21,22)23)8-12(26-18(14)29-16)13-2-1-7-28-13/h1-8H,24H2,(H,25,27)
SMILES string
NC1=C(C(NC2=CC=C(F)C=C2)=O)SC3=C1C(C(F)(F)F)=CC(C4=CC=CS4)=N3
InChI key
ZATJMMZPGVDUOM-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder (flocculent)
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
FDI-6是FOXM1的一种有效且特异性抑制剂。
FDI-6是FOXM1的一种有效且特异性抑制剂，其可可阻止DNA的结合。FDI-6可与FOXM1蛋白结合，并特异性下调FOXM1激活的基因。
叉头结构域抑制剂6（FDI-6）可用于治疗因血液生成减少而导致贫血的患者。在Hep-2细胞中，FDI-6可以刺激细胞死亡，还有助于防止细胞增殖、侵袭和迁移。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Andrew P Sawaya et al.
Nature communications, 11(1), 4678-4678 (2020-09-18)
Diabetic foot ulcers (DFUs) are a life-threatening disease that often result in lower limb amputations and a shortened lifespan. However, molecular mechanisms contributing to the pathogenesis of DFUs remain poorly understood. We use next-generation sequencing to generate a human dataset
Susana Ros et al.
Cancer cell, 38(4), 516-533 (2020-09-26)
PIK3CA, encoding the PI3Kα isoform, is the most frequently mutated oncogene in estrogen receptor (ER)-positive breast cancer. Isoform-selective PI3K inhibitors are used clinically but intrinsic and acquired resistance limits their utility. Improved selection of patients that will benefit from these
Loss of Forkhead box M1 promotes erythropoiesis through increased proliferation of erythroid progenitors
Youn M, et al.
Haematologica, 102(5), 826-834 (2017)
Forkhead domain inhibitor-6 (FDI-6) increases apoptosis and inhibits invasion and migration of laryngeal carcinoma cells by down-regulating nuclear FoxM1
Liu Y, et al.
Chinese Journal of Catalysis, 33(5), 611-616 (2017)
Karan Ulhaka et al.
International journal of molecular sciences, 22(13) (2021-07-03)
Triple-negative breast cancer (TNBC) presents an important clinical challenge, as it does not respond to endocrine therapies or other available targeting agents. FOXM1, an oncogenic transcriptional factor, has reported to be upregulated and associated with poor clinical outcomes in TNBC
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