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SML1394

奥美沙坦

Name: 奥美沙坦
Brand: SIGMA

≥98% (HPLC), Angiotensin II Type I receptor blocker, powder

别名:

4-（1-羟基-1-甲基乙基）-2-丙基-1- [ [2′--（2H-四唑-5-基） [1,1′--联苯 ]-4-基 ] 甲基 ]-1H-咪唑-5-羧酸, 奥美沙坦酸

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关于此项目

经验公式（希尔记法）:

C₂₄H₂₆N₆O₃

化学文摘社编号:

144689-24-7

分子量:

446.50

UNSPSC Code:

12352200

PubChem Substance ID:

329825842

NACRES:

NA.77

MDL number:

MFCD09749896

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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产品名称

奥美沙坦, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(C)(C)C1=C(C(O)=O)N(CC2=CC=C(C3=C(C4=NNN=N4)C=CC=C3)C=C2)C(CCC)=N1

InChI

1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)

InChI key

VTRAEEWXHOVJFV-UHFFFAOYSA-N

Gene Information

human ... AGTR1(185)

Application

奥美沙坦已用作血管紧张素 II 受体 1（AT1）的受体抑制剂，用于研究血管紧张素 II 1 型受体相互作用在调节血管紧张素 II 依赖性高血压中肾传入小动脉的作用。

Biochem/physiol Actions

奥美沙坦具有抗炎和抗氧化应激特性。它保护神经元细胞免于低聚淀粉样蛋白β（Aβ）诱导的细胞衰老。

奥美沙坦是一种血管紧张素 ⅡⅠ 型受体阻滞剂。

奥美沙坦是一种血管紧张素 ⅡⅠ 型受体阻滞剂。奥美沙坦是降压药奥美沙坦酯的活性形式。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Development and Validation of a Chromatography Method Using Tandem UV/Charged Aerosol Detector for Simultaneous Determination of Amlodipine Besylate and Olmesartan Medoxomil: Application to Drug-Excipient Compatibility Study.

Ariadne M Brondi et al.

Journal of analytical methods in chemistry, 2017, 4878316-4878316 (2018-02-03)

A study was carried out to investigate compatibility of amlodipine besylate and olmesartan medoxomil with a variety of pharmaceutical excipients. Both drugs are antihypertensive agents that can be administered alone, in monotherapy, or in pharmaceutical association. The studies were performed

Cardiovascular and Renal Outcomes of Renin-Angiotensin System Blockade in Adult Patients with Diabetes Mellitus: A Systematic Review with Network Meta-Analyses.

Ferrán Catalá-López et al.

PLoS medicine, 13(3), e1001971-e1001971 (2016-03-10)

Medications aimed at inhibiting the renin-angiotensin system (RAS) have been used extensively for preventing cardiovascular and renal complications in patients with diabetes, but data that compare their clinical effectiveness are limited. We aimed to compare the effects of classes of

Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis.

C Custodero et al.

Ageing research reviews, 46, 42-59 (2018-05-29)

Growing evidence suggests chronic low-grade inflammation (LGI) as a possible mechanism underlying the aging process. Some biological and pharmaceutical compounds may reduce systemic inflammation and potentially avert functional decline occurring with aging. The aim of the present meta-analysis was to

Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats.

Nanako Muraya et al.

Oxidative medicine and cellular longevity, 2018, 7635274-7635274 (2018-07-04)

Oxidative stress induced by hyperuricemia is closely associated with the renin-angiotensin system, as well as the onset and progression of cardiovascular disease (CVD) and chronic kidney disease (CKD). It is therefore important to reduce oxidative stress to treat hyperuricemia. We

Synergistic, cytotoxic and apoptotic activities of olmesartan with NF-κB inhibitor against HeLa human cell line.

Elham Bakhtiari et al.

Toxicology mechanisms and methods, 25(8), 614-621 (2015-09-04)

Over expression of renin-angiotensin system (RAS) and nuclear factor-kappaB (NF-κB) has a major role in many cancers. It has been suggested that some angiotensin receptor blockers (ARBs) could reduce the proliferation of cancer cells. The role of NF-κB pathway has

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全球贸易项目编号

货号	GTIN
SML1394-50MG	04061837107917

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