SML1401
XL413 hydrochloride
≥98% (HPLC), serine-threonine kinase CDC7 inhibitor, powder
别名:
(S)-8-Chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride, BMS-863233, XL-413
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关于此项目
经验公式（希尔记法）:
C14H12ClN3O2 · xHCl
化学文摘社编号:
分子量:
289.72 (free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
XL413 hydrochloride, ≥98% (HPLC)
SMILES string
ClC1=CC2=C(C=C1)OC3=C2N=C([C@H]4NCCC4)NC3=O.C
InChI
1S/C14H12ClN3O2.CH4/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9;/h3-4,6,9,16H,1-2,5H2,(H,17,18,19);1H4/t9-;/m0./s1
InChI key
UYBMDYGAVMHMGF-FVGYRXGTSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 5 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
XL413 is a selective inhibitor of the serine-threonine kinase CDC7 (cell division cycle 7 homolog), a regulator of cell cycle checkpoint control that has been implicated in protecting tumor cells from apoptotic cell death during replication stress. XL413 has an IC50 of 3.4 nM for CDC7, compared to 215 nM, 42 nM and 18 nM for CK2, PIM1 and pMCM2, respectively. XL413 caused significant tumor growth regression in rodent models, causing cell cycle arrest in the late S to G2 phase.
XL413 is a selective inhibitor of the serine-threonine kinase CDC7.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Yuichiro Saito et al.
Journal of cell science, 133(12) (2020-05-22)
RIF1 controls both DNA replication timing and the DNA double-strand break (DSB) repair pathway to maintain genome integrity. However, it remains unclear how RIF1 links these two processes following exposure to ionizing radiation (IR). Here, we show that inhibition of
Mehdi Bouhaddou et al.
Cell, 182(3), 685-712 (2020-07-10)
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to develop antiviral therapies. Here we present a
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