SML1414
利普司他丁-1
>98% (HPLC), powder, ferroptosis inhibitor
别名:
N-[（3-氯苯基）甲基] 螺-[4H-喹喔啉-3,4′-哌啶 ]-2-胺, N-[（3-氯苯基）甲基]-螺 [哌啶-4,2′ (1′H)-喹喔啉]-3′-胺
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关于此项目
经验公式（希尔记法）:
C19H21ClN4
化学文摘社编号:
分子量:
340.85
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
利普司他丁-1, >98% (HPLC)
SMILES string
ClC1=CC(CNC2=NC3=CC=CC=C3NC24CCNCC4)=CC=C1
InChI
1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)
InChI key
YAFQFNOUYXZVPZ-UHFFFAOYSA-N
assay
>98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
Quality Level
Application
Liproxstatin-1 在细胞活力试验和脂质过氧化测定中用作细胞死亡抑制剂。
Biochem/physiol Actions
Liproxstatin-1 是铁死亡的强效抑制剂。
Liproxstatin-1 是铁死亡的强效抑制剂，铁死亡是一种非凋亡形式的细胞死亡，以铁依赖性致死脂质活性氧簇 (ROS) 蓄积为特征。Liproxstatin-1 在人类细胞和缺血/再灌注诱导的小鼠组织损伤模型中抑制了铁死亡。谷胱甘肽过氧化物酶 4 (Gpx4) 的基因敲除已被证明可引起细胞死亡的铁死亡。Liproxstatin-1 能够抑制 Gpx4 基因敲除小鼠的铁死亡。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis.
Ingold I, et al.
Cell, 172(3), 409-422 (2018)
Wen-Hsuan Yang et al.
Molecular cancer research : MCR, 18(1), 79-90 (2019-10-24)
Ovarian cancer is the deadliest gynecologic cancer. Despite recent advances, clinical outcomes remain poor, necessitating novel therapeutic approaches. To investigate metabolic susceptibility, we performed nutrigenetic screens on a panel of clear cell and serous ovarian cancer cells and identified cystine
Alejandra M Martinez et al.
FEBS open bio, 9(4), 582-593 (2019-04-16)
Ferroptosis is a form of regulated cell death that is driven by lethal accumulation of lipid peroxides upon inhibition of glutathione peroxidase 4 (GPx4). Deletion of the Gpx4 gene in mice revealed that neurons are sensitive to ferroptosis in vivo. However
Yilei Zhang et al.
Nature cell biology, 20(10), 1181-1192 (2018-09-12)
The roles and regulatory mechanisms of ferroptosis (a non-apoptotic form of cell death) in cancer remain unclear. The tumour suppressor BRCA1-associated protein 1 (BAP1) encodes a nuclear deubiquitinating enzyme to reduce histone 2A ubiquitination (H2Aub) on chromatin. Here, integrated transcriptomic
Ji-Yoon Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(51), 32433-32442 (2020-12-09)
Ferroptosis is an iron-dependent regulated necrosis mediated by lipid peroxidation. Cancer cells survive under metabolic stress conditions by altering lipid metabolism, which may alter their sensitivity to ferroptosis. However, the association between lipid metabolism and ferroptosis is not completely understood.
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