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SML1414

利普司他丁-1

Name: 利普司他丁-1
Brand: SIGMA

>98% (HPLC), powder, ferroptosis inhibitor

别名:

N-[（3-氯苯基）甲基] 螺-[4H-喹喔啉-3,4′-哌啶 ]-2-胺, N-[（3-氯苯基）甲基]-螺 [哌啶-4,2′ (1′H)-喹喔啉]-3′-胺

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关于此项目

经验公式（希尔记法）:

C₁₉H₂₁ClN₄

化学文摘社编号:

950455-15-9

分子量:

340.85

UNSPSC Code:

12352200

PubChem Substance ID:

329825860

NACRES:

NA.77

MDL number:

MFCD14948691

Assay:

>98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

利普司他丁-1, >98% (HPLC)

Quality Level

100

assay

>98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

ClC1=CC(CNC2=NC3=CC=CC=C3NC24CCNCC4)=CC=C1

InChI

1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)

InChI key

YAFQFNOUYXZVPZ-UHFFFAOYSA-N

说明

Application

Liproxstatin-1 在细胞活力试验和脂质过氧化测定中用作细胞死亡抑制剂。

Biochem/physiol Actions

Liproxstatin-1 是铁死亡的强效抑制剂。

Liproxstatin-1 是铁死亡的强效抑制剂，铁死亡是一种非凋亡形式的细胞死亡，以铁依赖性致死脂质活性氧簇 (ROS) 蓄积为特征。Liproxstatin-1 在人类细胞和缺血/再灌注诱导的小鼠组织损伤模型中抑制了铁死亡。谷胱甘肽过氧化物酶 4 (Gpx4) 的基因敲除已被证明可引起细胞死亡的铁死亡。Liproxstatin-1 能够抑制 Gpx4 基因敲除小鼠的铁死亡。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

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Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis.

Ingold I, et al.

Cell, 172(3), 409-422 (2018)

NSC-34 motor neuron-like cells are sensitized to ferroptosis upon differentiation.

Alejandra M Martinez et al.

FEBS open bio, 9(4), 582-593 (2019-04-16)

Ferroptosis is a form of regulated cell death that is driven by lethal accumulation of lipid peroxides upon inhibition of glutathione peroxidase 4 (GPx4). Deletion of the Gpx4 gene in mice revealed that neurons are sensitive to ferroptosis in vivo. However

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion.

Yilong Zou et al.

Nature, 585(7826), 603-608 (2020-09-18)

Ferroptosis-an iron-dependent, non-apoptotic cell death process-is involved in various degenerative diseases and represents a targetable susceptibility in certain cancers1. The ferroptosis-susceptible cell state can either pre-exist in cells that arise from certain lineages or be acquired during cell-state transitions2-5. However

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全球贸易项目编号

货号	GTIN
SML1414-25MG	04061833066829
SML1414-5MG	04061837107924