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Merck
CN

SML1415

Sigma-Aldrich

VE-821

≥98% (HPLC)

别名:

3-氨基-6-(4-(甲磺酰基)苯基)-N-苯基吡嗪-2-甲酰胺, 3-氨基-6-[4-(甲磺酰基)苯基]-N-苯基-2-吡嗪甲酰胺, VE821

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W400201-SAMPLE
¥404.65
1 KG
¥894.24
5 KG
¥2,275.00
10 KG
¥3,804.88

¥404.65


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W400201-SAMPLE
¥404.65
1 KG
¥894.24
5 KG
¥2,275.00
10 KG
¥3,804.88

About This Item

经验公式(希尔记法):
C18H16N4O3S
CAS Number:
分子量:
368.41
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

¥404.65


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质量水平

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: ≥10 mg/mL, clear

储存温度

−20°C

SMILES字符串

CS(C(C=C1)=CC=C1C2=NC(C(NC3=CC=CC=C3)=O)=C(N)N=C2)(=O)=O

InChI

1S/C18H16N4O3S/c1-26(24,25)14-9-7-12(8-10-14)15-11-20-17(19)16(22-15)18(23)21-13-5-3-2-4-6-13/h2-11H,1H3,(H2,19,20)(H,21,23)

InChI key

DUIHHZKTCSNTGM-UHFFFAOYSA-N

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GF23017216GF21499544GF40348065
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钼 foil, 6mm disks, thickness 0.025mm, annealed, 99.9%

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钼 foil, 6mm disks, thickness 0.075mm, annealed, 99.9%

GF21499544

钼 foil, 6mm disks, thickness 0.020mm, annealed, 99.9%

GF40348065

assay

99.9%

assay

99.90%

assay

99.90%

assay

99.9%

manufacturer/tradename

Goodfellow 575-073-74

manufacturer/tradename

Goodfellow 230-172-16

manufacturer/tradename

Goodfellow 214-995-44

manufacturer/tradename

Goodfellow 403-480-65

form

foil

form

foil

form

foil

form

foil

mp

2617 °C (lit.)

mp

2617 °C (lit.)

mp

2617 °C (lit.)

mp

2617 °C (lit.)

density

10.3 g/mL at 25 °C (lit.)

density

10.3 g/mL at 25 °C (lit.)

density

10.3 g/mL at 25 °C (lit.)

density

10.3 g/mL at 25 °C (lit.)

bp

4612 °C (lit.)

bp

4612 °C (lit.)

bp

4612 °C (lit.)

bp

4612 °C (lit.)

应用

VE-821 已用作人癌细胞中 ATM 和 Rad3 相关(ATR)蛋白的抑制剂。[1]

生化/生理作用

VE-821 是 ATP 竞争性 ATR 抑制剂。
VE-821 是一种有效的 ATP 竞争性抑制剂,可抑制 DNA 损伤应答(DDR)激酶共济失调毛细血管扩张突变(ATM)以及与 ATM 和 Rad3 相关(ATR),Ki 值为 13 nM。VE-821 对相关 PIKKs ATM、DNA 依赖性蛋白激酶(DNA-PK)、mTOR 和 PI3-激酶-γ 的交叉反应极小(Ki 值分别为 16 μM、2.2 μM、>1 μM 和 3.9 μM),并针对大量无关的蛋白激酶。在大部分癌细胞中单独使用 VE-821 会导致细胞死亡,并且还显示出与遗传毒性剂的强大协同作用。VE-821 增加了细胞对放射线的敏感性,并使癌细胞对多种化学治疗剂敏感。

其他说明

VE-821 已由化学探针门户网站进行了专家审查和推荐。有关更多信息,请访问化学探针门户网站上的 VE-821 探针摘要

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

危险化学品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Charles F Baker et al.
Dalton transactions (Cambridge, England : 2003), (9)(9), 1298-1303 (2004-07-15)
New molybdenum(VI) nitride oxides were synthesised by the reaction of strontium nitride and calcium nitride with molybdenum foil at high temperature in sealed stainless steel crucibles. The reactions yielded single crystalline products determined by X-ray diffraction to form complex structures
Dattatray J Late et al.
Nanotechnology, 19(26), 265605-265605 (2008-07-02)
Nanocrystalline lanthanum hexaboride (LaB(6)) films have been deposited on molybdenum foil by the pulsed laser deposition (PLD) technique. The as-deposited films were characterized by x-ray diffraction (XRD), scanning electron microscopy (SEM) and atomic force microscopy (AFM). The XRD pattern shows
J G Watkins et al.
The Review of scientific instruments, 79(10), 10F125-10F125 (2008-12-03)
Two modular arrays of Langmuir probes designed to handle a heat flux of up to 25 MW/m(2) for 10 s exposures have been installed in the lower divertor target plates of the DIII-D tokamak. The 20 pyrolytic graphite probe tips
Michael N Evans
Rapid communications in mass spectrometry : RCM, 22(14), 2211-2219 (2008-06-11)
A reactor for converting cellulose into carbon monoxide for subsequent oxygen isotopic analysis via continuous flow isotope ratio mass spectrometry is described. The system employs an induction heater to produce temperatures >or=1500 degrees C within a molybdenum foil crucible positioned
Ralf R Mendel et al.
Biochimica et biophysica acta, 1823(9), 1568-1579 (2012-03-01)
The transition element molybdenum (Mo) needs to be complexed by a special cofactor in order to gain catalytic activity. With the exception of bacterial Mo-nitrogenase, where Mo is a constituent of the FeMo-cofactor, Mo is bound to a pterin, thus

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