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Merck
CN

SML1438

LY2090314

≥98% (HPLC)

别名:

3-[9-Fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepin-7-yl]-4-imidazo[1,2-a]pyridin-3-yl-1h-pyrrole-2,5-dione, 3-[9-Fluoro-2-(piperidin-1-ylcarbonyl)-1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indol-7-yl]-4-imidazo[1,2-a]pyridin-3-yl-1H-pyrrole-2,5-dione, LY-2090314

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关于此项目

经验公式（希尔记法）:
C28H25FN6O3
化学文摘社编号:
603288-22-8
分子量:
512.53
NACRES:
NA.77
PubChem Substance ID:
329825878
UNSPSC Code:
12352200
MDL number:
MFCD20526532

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产品名称

LY2090314, ≥98% (HPLC)

InChI

1S/C28H25FN6O3/c29-18-12-17-15-34(28(38)32-7-3-1-4-8-32)11-10-33-16-20(19(13-18)25(17)33)23-24(27(37)31-26(23)36)21-14-30-22-6-2-5-9-35(21)22/h2,5-6,9,12-14,16H,1,3-4,7-8,10-11,15H2,(H,31,36,37)

SMILES string

O=C(N1CCCCC1)N(C2)CCN3C4=C2C=C(F)C=C4C(C5=C(C6=CN=C7N6C=CC=C7)C(NC5=O)=O)=C3

InChI key

HRJWTAWVFDCTGO-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

yellow to orange

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Gene Information

human ... GSK3A(2931), GSK3B(2932)

相关类别

Biochem/physiol Actions

LY2090314 can decrease the development of human MYCN amplified and non-amplified neuroblastoma (NB) cell lines in vitro. It has the ability to prevent the multiplication, colony formation and cell confluency of neuroblastoma.
LY2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) currently in clinical trials for cancer therapy. LY2090314 has IC50 values of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β, respectively.
LY2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3).

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000455007
0000455003
0000455003
0000455007
0000393683

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Antiproliferative and apoptotic effect of LY2090314, a GSK-3 inhibitor, in neuroblastoma in vitro
Kunnimalaiyaan S, et al.
BMC Cancer, 18(1), 560-560 (2018)
Mengfei Yu et al.
Cell, 184(1), 243-256 (2021-01-09)
Craniosynostosis results from premature fusion of the cranial suture(s), which contain mesenchymal stem cells (MSCs) that are crucial for calvarial expansion in coordination with brain growth. Infants with craniosynostosis have skull dysmorphology, increased intracranial pressure, and complications such as neurocognitive

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