SML1448
环黄芪醇
≥98% (HPLC)
别名:
GRN510, TAT2, 环孢菌素, 环孢菌素原, 黄芪黄素, (3β,6α,16β,20R,24S)- 20,24-环氧-9,19-环羊毛烷-3,6,16,25-四醇, 环黄芪醇
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关于此项目
经验公式（希尔记法）:
C30H50O5
化学文摘社编号:
分子量:
490.72
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +45 to +60°, c = 1 in methanol
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
C[C@]1(O[C@H](C(O)(C)C)CC1)[C@@]2([H])[C@@H](O)C[C@@]3(C)[C@]4([H])C[C@H](O)[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C6)[C@]46CC[C@@]32C
InChI
1S/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21-,22-,23-,26+,27-,28+,29-,30+/m0/s1
InChI key
WENNXORDXYGDTP-UOUCMYEWSA-N
General description
环雌三醇从 黄芪 属物种中分离得到。
Biochem/physiol Actions
环雌三醇是从黄芪属物种中分离出的一种黄芪甲苷的糖苷配基，其具有抗炎特性，可促进伤口愈合和闭合伤口。 环雌三醇可增强人CD8+T淋巴细胞的抗病毒应答。 环雌三醇在人新生儿角质形成细胞、PC12细胞和原代神经元中可诱导端粒酶活性并诱导CREB（cAMP反应元件结合）激活。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Claude Jourdan Le Saux et al.
PloS one, 8(3), e58423-e58423 (2013-03-22)
The emergence of diseases associated with telomere dysfunction, including AIDS, aplastic anemia and pulmonary fibrosis, has bolstered interest in telomerase activators. We report identification of a new small molecule activator, GRN510, with activity ex vivo and in vivo. Using a
Steven Russell Fauce et al.
Journal of immunology (Baltimore, Md. : 1950), 181(10), 7400-7406 (2008-11-05)
Telomerase reverse transcribes telomere DNA onto the ends of linear chromosomes and retards cellular aging. In contrast to most normal somatic cells, which show little or no telomerase activity, immune cells up-regulate telomerase in concert with activation. Nevertheless, during aging
Fanny C F Ip et al.
Neuro-Signals, 22(1), 52-63 (2014-08-07)
Cycloastragenol (CAG) is an aglycone of astragaloside IV. It was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. The present study demonstrates that CAG stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. In
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1448-25MG | 04061833066881 |
| SML1448-5MG | 04061833066898 |