SML1449

G3335

Name: G3335
Brand: SIGMA

≥98% (HPLC)

别名:

H-Trp-Glu-OH, L-Tryptophyl-L-glutamic acid, WE

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₉N₃O₅

化学文摘社编号:

36099-95-3

分子量:

333.34

UNSPSC Code:

12352200

NACRES:

NA.77

主要文件

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SMILES string

[nH]1c2c(c(c1)C[C@H](N)C(=O)N[C@@H](CCC(=O)O)C(=O)O)cccc2

InChI

1S/C16H19N3O5/c17-11(7-9-8-18-12-4-2-1-3-10(9)12)15(22)19-13(16(23)24)5-6-14(20)21/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/m0/s1

InChI key

PWIQCLSQVQBOQV-AAEUAGOBSA-N

assay

≥98% (HPLC)

form

powder

color

white to off-white

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

G3335 ( L-tryptophyl-L-glutamic acid) is a cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist with a Kd value of 8.34 μM for PPARγ and much lower activity at other PPAR subtypes. G3335 reversibly and competitively blocks activation of PPARγ by the PPARγ agonist rosiglitazone, and conversely, in rat astrocyte culture higher levels of rosiglitazone reduced harmful effects induced by G3335. At higher concentration G3335 may act as a PPARα agonist, interacting with the PPARα ligand binding domain with a KD of 120 μM. G3335 is reported to reduce hepatic lipid accumulation in lipid-loaded hepatocytes by activation of PPARα.

G3335 ( L-tryptophyl-L-glutamic acid) is a cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist.