SML1466
ABH 盐酸盐
≥98% (HPLC), arginase inhibitor, powder
别名:
2（S）-氨基-6-硼己酸 盐酸盐, 6-硼-L-正亮氨酸 盐酸盐
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关于此项目
经验公式（希尔记法）:
C6H14BNO4 · HCl
化学文摘社编号:
分子量:
211.45
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
ABH 盐酸盐, ≥98% (HPLC)
SMILES string
OB(O)CCCC[C@H](N)C(O)=O.[H]Cl
InChI
1S/C6H14BNO4.ClH/c8-5(6(9)10)3-1-2-4-7(11)12;/h5,11-12H,1-4,8H2,(H,9,10);1H/t5-;/m0./s1
InChI key
XCUVEZUCSHVMRK-JEDNCBNOSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +8 to +13°, c = 0.7 in H2O
storage condition
desiccated
color
white to beige
solubility
H2O: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
ABH 是一种高效且特异的精氨酸酶抑制剂
ABH（2（S）-氨基-6-硼己酸）是一种高效且特异的精氨酸酶抑制剂，可在 COPD 啮齿动物模型中抑制 LPS 诱导的肺 IL-8、中性粒细胞和杯状细胞以及气道纤维化的增加。
已知在动物模型中 ABH 对精氨酸酶的选择性抑制可改善 1 型糖尿病、自身免疫性脑炎、慢性哮喘和因衰老引起的血管僵硬的影响。ABH 对精氨酸酶的抑制作用可恢复衰老小鼠的勃起血流动力学。体外研究证明，ABH 可增强一氧化氮刺激的平滑肌松弛作用。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Yvonne Grobben et al.
Journal of structural biology: X, 4, 100014-100014 (2020-07-11)
Arginase-1 is a manganese-dependent metalloenzyme that catalyzes the hydrolysis of L-arginine into L-ornithine and urea. Arginase-1 is abundantly expressed by tumor-infiltrating myeloid cells that promote tumor immunosuppression, which is relieved by inhibition of Arginase-1. We have characterized the potencies of
Chronic oral administration of the arginase inhibitor 2 (S)?amino?6?boronohexanoic acid (ABH) improves erectile function in aged rats.
Segal R, et al.
Journal of Andrology, 33(6), 1169-1175 (2012)
Structure and function of arginases.
Ash D E.
The Journal of Nutrition, 134(10), 2760S-2764S (2004)
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