SML1467
ASP7663
≥98% (HPLC)
别名:
(2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid, (E)-[7-Fluoro-1-(2-methylpropyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]acetic acid
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关于此项目
经验公式（希尔记法）:
C14H14FNO3
化学文摘社编号:
分子量:
263.26
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
SMILES string
CC(C)CN(C1=C(F)C=CC=C1/C2=C\C(O)=O)C2=O
InChI
1S/C14H14FNO3/c1-8(2)7-16-13-9(4-3-5-11(13)15)10(14(16)19)6-12(17)18/h3-6,8H,7H2,1-2H3,(H,17,18)/b10-6+
InChI key
RCVZUIGCNAAMIC-UXBLZVDNSA-N
assay
≥98% (HPLC)
form
powder
color
light orange to dark orange
solubility
DMSO: 25 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
ASP7663 is a selective activator of transient receptor potential ankyrin 1 (TRPA1), known to play a role for chemical sensing in the pain pathway. ASP7663 activated human, rat, and mouse TRPA1 receptors with EC50 values of 510, 540, and 500 nM, respectively, and little or no affinity at more than 60 other related receptors, channels and enzymes. ASP7663 enhanced colonic motility and exerted analgesic effects against abdominal pain in mouse models.
ASP7663 is a selective activator of transient receptor potential ankyrin 1 (TRPA1).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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