SML1469
Ulipristal acetate
≥98% (HPLC)
别名:
(11β)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione, CDB-2914
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关于此项目
经验公式（希尔记法）:
C30H37NO4
化学文摘社编号:
分子量:
475.62
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
产品名称
Ulipristal acetate, ≥98% (HPLC)
InChI
1S/C30H37NO4/c1-18(32)30(35-19(2)33)15-14-27-25-12-8-21-16-23(34)11-13-24(21)28(25)26(17-29(27,30)3)20-6-9-22(10-7-20)31(4)5/h6-7,9-10,16,25-27H,8,11-15,17H2,1-5H3/t25-,26+,27-,29-,30-/m0/s1
SMILES string
O=C(C)[C@@]1(OC(C)=O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CCC4=C3[C@@H](C5=CC=C(N(C)C)C=C5)C[C@@]21C)=O
InChI key
OOLLAFOLCSJHRE-ZHAKMVSLSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +165 to +185°, c = 1 in dichloromethane
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
−20°C
Quality Level
Gene Information
human ... PGR(5241)
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Biochem/physiol Actions
Ulipristal acetate is a selective progesterone receptor modulator (SPRM) with tissue-selective partial antagonist activity. It has clinical use both as an emergency contraceptive and as a treatment for uterine fibroids. Ulipristal acetate acts as a partial antagonist on the hypothalamic–pituitary–ovarian axis to inhibit or delay ovulation without affecting human embryo implantation. As a progesterone antagonist, Ulipristal acetate selectively suppresses neo-vascularization, cell proliferation, and survival in uterine fibroid cells, but not in normal myometrial cells.
Ulipristal acetate is a selective progesterone receptor modulator (SPRM); contraceptive and treatment for fibroid tumors.
Ulipristal acetate is known to reduce uncontrolled bleeding due to post uterine fibroid surgery.
signalword
Warning
hcodes
Hazard Classifications
Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Ulipristal acetate versus placebo for fibroid treatment before surgery.
Donnez J, et al.
The New England Journal of Medicine, 366(5), 409-420 (2012)
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