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Merck
CN

SML1480

Alclometasone dipropionate

≥98% (HPLC)

别名:

Alclometasone Dipropanoate, Sch 22219, (7α,11β,16α)-7-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione, 7α-Chloro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate), Alclometasone 17,21-dipropionate

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关于此项目

经验公式（希尔记法）:
C28H37ClO7
化学文摘社编号:
66734-13-2
分子量:
521.04
UNSPSC Code:
12352200
EC Number:
266-464-3
NACRES:
NA.77

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SMILES string

Cl[C@H]1[C@@H]2[C@@H]([C@@]4(C(=CC(=O)C=C4)C1)C)[C@H](C[C@]3([C@H]2C[C@H]([C@]3(OC(=O)CC)C(=O)COC(=O)CC)C)C)O

InChI key

DJHCCTTVDRAMEH-DUUJBDRPSA-N

InChI

1S/C28H37ClO7/c1-6-22(33)35-14-21(32)28(36-23(34)7-2)15(3)10-18-24-19(29)12-16-11-17(30)8-9-26(16,4)25(24)20(31)13-27(18,28)5/h8-9,11,15,18-20,24-25,31H,6-7,10,12-14H2,1-5H3/t15-,18+,19-,20+,24-,25+,26+,27+,28+/m1/s1

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

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Biochem/physiol Actions

Alclometasone dipropionate is a glucocorticoid receptor agonist that mimics the metabolic, anti-inflammatory, immunosuppressive, antipruritic, and vasoconstrictive effects of natural glucocorticoids.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361

Hazard Classifications

Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000071349
0000071348
046M4734V

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S Aoyama et al.
Drug metabolism and disposition: the biological fate of chemicals, 18(4), 409-417 (1990-07-01)
The metabolic fate of alclometasone dipropionate (ADP or S-3460) has been studied in rats, rabbits, and mice, with consideration of their interspecies differences. Several reference compounds related to ADP were synthesized for the determination and identification of the metabolites. After
Y Nishibe et al.
Japanese journal of pharmacology, 50(4), 435-443 (1989-08-01)
The effect of successive administration of the corticosteroid alclometasone dipropionate (ACM) on the hepatic drug-metabolizing system was examined using male and female rats. Although some pharmacological changes such as increases in plasma enzyme activity, lipid level and protein concentration appeared

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