跳转至内容
Merck
CN

SML1490

培美曲塞 二钠 七水合物

≥98% (HPLC)

别名:

HSDB 7316, LY 231,514, LY 231514, N-（4-（2-（2-氨基-3,4-二氢-4-氧代-7H-吡咯并（2,3-d）嘧啶-5-基）乙基）苯甲酰基）谷氨酸 钠盐 水合物, N-（4-（2-（2-氨基-4,7-二氢-4-氧代-1H-吡咯并（2,3-d）嘧啶-5-基）乙基）苯甲酰基）-L-谷氨酸 钠盐 水合物, UNII-04Q9AIZ7NO

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C20H19N5O6 · 2Na · 7H2O
化学文摘社编号:
357166-29-1
分子量:
597.48
UNSPSC Code:
12352200
NACRES:
NA.77

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

培美曲塞 二钠 七水合物, ≥98% (HPLC)

SMILES string

[Na+].[Na+].[nH]1c2[nH]cc(c2[c](nc1N)=O)CCc3ccc(cc3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.O.O

InChI

1S/C20H21N5O6.2Na.7H2O/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;;;;;;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;;7*1H2/q;2*+1;;;;;;;/p-2/t13-;;;;;;;;;/m0........./s1

InChI key

QJVSMHJWAOSBMD-MYXYZBIASA-L

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 30 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Application

该培美曲塞(Pemetrexed)二钠七水合物已用于研究其作为抗叶酸代谢类药物，对卵巢透明细胞癌细胞的影响。作为抗叶酸剂，也用于研究其对神经母细胞瘤细胞系的影响。

Biochem/physiol Actions

培美曲塞对多种肿瘤具有抗性，包括结直肠、乳腺、胃、胰腺和宫颈癌。它是多重耐药转运蛋白的外排底物。
培美曲塞是一种被批准用于治疗包括胸膜间皮瘤和非小细胞肺癌在内的多种癌症的抗叶酸药物。
培美曲塞是一种被批准用于治疗包括胸膜间皮瘤和非小细胞肺癌在内的多种癌症的抗叶酸药物。培美曲塞是一种叶酸抗代谢物，可抑制用于嘌呤和嘧啶合成的三种酶，即胸苷酸合酶、二氢叶酸还原酶和甘氨酰胺核糖核苷酸甲酰转移酶。

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Muta. 2 - Repr. 1A - Skin Irrit. 2 - STOT RE 1

target_organs

Blood,Immune system,Testes

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000159305
0000207781
0000154822
0000207781

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Alex A Adjei
Clinical cancer research : an official journal of the American Association for Cancer Research, 10(12 Pt 2), 4276s-4280s (2004-06-26)
Pemetrexed (ALIMTA, LY231514, MTA) is a novel antimetabolite that inhibits at least three enzymes involved in the folate pathway. These enzymes are thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase. Pemetrexed has demonstrated clinical activity in non-small cell lung cancer
Pooyeh Farahmand et al.
Frontiers in toxicology, 5, 1200650-1200650 (2023-07-13)
Hypothesis: Asbestos-driven inflammation contributes to malignant pleural mesothelioma beyond the acquisition of rate-limiting mutations. Methods: Genetically modified conditional allelic mice that were previously shown to develop mesothelioma in the absence of exposure to asbestos were induced with lentiviral vector expressing
Ning Mu et al.
Cell death & disease, 14(9), 645-645 (2023-10-01)
Brain expressed X-linked gene 2 (BEX2) encoded protein was originally identified to promote transcription by interacting with several transcription factors in the DNA-binding complexes. Recently, BEX2 was found to be localized in cytosol and/or mitochondria and regulate apoptosis in cancer
Ken Yamashita et al.
Cancer science, 111(7), 2431-2439 (2020-05-18)
MYCN gene amplification is consistently associated with poor prognosis in patients with neuroblastoma, a pediatric tumor arising from the sympathetic nervous system. Conventional anticancer drugs, such as alkylating agents and platinum compounds, have been used for the treatment of high-risk
Ping Tian et al.
PloS one, 19(2), e0298295-e0298295 (2024-02-14)
Timeless is well-known for its key role in replication checkpoints. Recent studies reveal the involvement of Timeless and specificity protein (SP) 1 in human malignancies. However, no evidence proved the interaction between SP3 and Timeless in lung adenocarcinoma (LUAD). The

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持