Merck
CN

SML1490

Sigma-Aldrich

培美曲塞 二钠 七水合物

≥98% (HPLC)

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别名:
HSDB 7316, LY 231,514, LY 231514, N-(4-(2-(2-氨基-3,4-二氢-4-氧代-7H-吡咯并(2,3-d)嘧啶-5-基)乙基)苯甲酰基)谷氨酸 钠盐 水合物, N-(4-(2-(2-氨基-4,7-二氢-4-氧代-1H-吡咯并(2,3-d)嘧啶-5-基)乙基)苯甲酰基)-L-谷氨酸 钠盐 水合物, UNII-04Q9AIZ7NO
Empirical Formula (Hill Notation):
C20H19N5O6 · 2Na · 7H2O
分子量:
597.48
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

H2O: 30 mg/mL, clear

储存温度

2-8°C

InChI

1S/C20H21N5O6.2Na.7H2O/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;;;;;;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;;7*1H2/q;2*+1;;;;;;;/p-2/t13-;;;;;;;;;/m0........./s1

InChI key

QJVSMHJWAOSBMD-MYXYZBIASA-L

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洛美曲索水合物

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

white to beige

color

white to off-white

color

white to light yellow

solubility

H2O: 30 mg/mL, clear

solubility

H2O: 2 mg/mL, clear

solubility

DMSO: ≥50 mg/mL

solubility

DMSO: ≥5 mg/mL

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

应用

该培美曲塞(Pemetrexed)二钠七水合物已用于研究其作为抗叶酸代谢类药物,对卵巢透明细胞癌细胞的影响。作为抗叶酸剂,也用于研究其对神经母细胞瘤细胞系的影响。

生化/生理作用

培美曲塞对多种肿瘤具有抗性,包括结直肠、乳腺、胃、胰腺和宫颈癌。它是多重耐药转运蛋白的外排底物。
培美曲塞是一种被批准用于治疗包括胸膜间皮瘤和非小细胞肺癌在内的多种癌症的抗叶酸药物。培美曲塞是一种叶酸抗代谢物,可抑制用于嘌呤和嘧啶合成的三种酶,即胸苷酸合酶、二氢叶酸还原酶和甘氨酰胺核糖核苷酸甲酰转移酶。

象形图

Exclamation markHealth hazard

警示用语:

Danger

危险分类

Muta. 2 - Repr. 1A - Skin Irrit. 2 - STOT RE 1

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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