SML1508
C-DIM12
≥98% (HPLC)
别名:
3,3′-[(4-Chlorophenyl)methylene]bis-1H-indole, 4-Chlorophenyl-3,3′-diindolylmethane, 4-Chlorophenyldi-3-indolylmethane
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关于此项目
经验公式（希尔记法）:
C23H17N2Cl
化学文摘社编号:
分子量:
356.85
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
C-DIM12, ≥98% (HPLC)
SMILES string
ClC(C=C1)=CC=C1C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5
InChI
1S/C23H17ClN2/c24-16-11-9-15(10-12-16)23(19-13-25-21-7-3-1-5-17(19)21)20-14-26-22-8-4-2-6-18(20)22/h1-14,23,25-26H
InChI key
LTLRXTDMXOFBDW-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
, light orange to dark red
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
C-DIM12 is a potent and selective nuclear receptor Nurr1 (NR4A2) activator that activates Nurr1 in urothelial carcinoma cells and in pancreatic cells. C-DIM12 suppresses inflammatory signaling in microglia.
C-DIM12 is a potent and selective nuclear receptor Nurr1 (NR4A2) activator.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Snehajyoti Chatterjee et al.
Neurobiology of aging, 85, 140-144 (2019-11-17)
Age-associated cognitive impairments affect an individual's quality of life and are a growing problem in society. Therefore, therapeutic strategies to treat age-related cognitive decline are needed to enhance the quality of life among the elderly. Activation of the Nr4a family
Qi-Wen Han et al.
Acta pharmacologica Sinica, 43(9), 2253-2266 (2022-02-09)
Neuroinflammation is closely related to the pathogenesis of neurodegenerative diseases. Activation of microglia, the resident immune cells in CNS, induces inflammatory responses, resulting in the release of neurotoxic molecules, which favors neuronal death and neurodegeneration. Nuclear receptor-related 1 (Nurr1) protein
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