SML1516
DS-437
≥98% (HPLC)
别名:
5′-S-[2-[[(Ethylamino)carbonyl]amino]ethyl]-5′-thio-adenosine
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C15H23N7O4S
化学文摘社编号:
分子量:
397.45
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
DS-437, ≥98% (HPLC)
SMILES string
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CSCCNC(NCC)=O)O3
InChI
1S/C15H23N7O4S/c1-2-17-15(25)18-3-4-27-5-8-10(23)11(24)14(26-8)22-7-21-9-12(16)19-6-20-13(9)22/h6-8,10-11,14,23-24H,2-5H2,1H3,(H2,16,19,20)(H2,17,18,25)/t8-,10+,11?,14-/m1/s1
InChI key
CACMCLIHCDTJHL-XNZUMOJTSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
Application
DS-437 has been used as an inhibitor of protein arginine methyltransferase 5 (PRMT5) to study its effect on forkhead box P3 (FOXP3) methylation and regulatory T cells (Tregs) function in 293T cells.
Biochem/physiol Actions
DS-437 inhibits regulatory T cells (Tregs) function and methylation of forkhead box P3 (FOXP3) in 293T cells. DS-437 in combination with anti-p185erbB2/neu antibody 4D5 reduces tumor growth in CT26HER2 tumor-bearing mice.
DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC50 5.9 and 6 μM) with little interaction against a panel of 30 other human methyltransferases.
DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7.
Other Notes
DS-437 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the DS-437 probe summary on the Chemical Probes Portal website.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Yasuhiro Nagai et al.
Frontiers in immunology, 10, 174-174 (2019-02-26)
Regulatory T cells (Tregs) are a subpopulation of T cells that are specialized in suppressing immune responses. Here we show that the arginine methyl transferase protein PRMT5 can complex with FOXP3 transcription factors in Tregs. Mice with conditional knock out
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持