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SML1529

Erdosteine

Name: Erdosteine
Brand: SIGMA

≥98% (HPLC), powder, mucolytic agent

别名:

({2-Oxo-2-[(2-oxotetrahydro-3-thienyl)amino]ethyl}sulfanyl)acetic acid, 2-[[2-Oxo-2-[(tetrahydro-2-oxo-3-thienyl)amino]ethyl]thio]acetic acid

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关于此项目

经验公式（希尔记法）:

C₈H₁₁NO₄S₂

化学文摘社编号:

84611-23-4

分子量:

249.31

UNSPSC Code:

12352200

PubChem Substance ID:

329825946

NACRES:

NA.77

MDL number:

MFCD00867664

Assay:

≥98% (HPLC)

Form:

powder

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属性

产品名称

Erdosteine, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

S1CCC(C1=O)NC(=O)CSCC(=O)O

InChI

1S/C8H11NO4S2/c10-6(3-14-4-7(11)12)9-5-1-2-15-8(5)13/h5H,1-4H2,(H,9,10)(H,11,12)

InChI key

QGFORSXNKQLDNO-UHFFFAOYSA-N

说明

General description

Erdosteine is a derivative of thiol, and is used in the treatment of chronic obstructive bronchitis, including acute infective exacerbation of chronic bronchitis.It consists of two blocked sulfhydryl groups, which are released following first-pass metabolism.

Application

Erdosteine has been used as a mucolytic to study its protective effects on interleukin-1β-stimulated inflammation in rat chondrocytes in osteoarthritis models.

Biochem/physiol Actions

Erdosteine is a mucolytic drug with expectorant and antitussive effects. Erdosteine is quickly metabolized in vivo to free thiols which act as free radical scavengers. Erdosteine has also been shown to have antioxidant activity through the activation of Nrf2-dependent antioxidant genes and inhibition of pro-inflammatory cytokines.

Erdosteine is a mucolytic drug with expectorant and antitussive effects.

象形图

GHS07

警示词

Warning

危险代码

H302

预防性声明

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

怎么回事？

WGK 3

闪点 (F)

Not applicable

闪点 (°C)