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SML1532

Cinaciguat hydrochloride

Name: Cinaciguat hydrochloride
Brand: SIGMA

≥98% (HPLC), guanylate cyclase activator, powder

别名:

4-[((4-Carboxybutyl){2-[(4-phenethylbenzyl)oxy]phenethyl}amino)methyl[benzoic]acid hydrochloride, 4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-benzoic acid hydrochloride, BAY 58-2667 hydrochloride, BAY582667 hydrochloride, UNII-59K0Y58UAD hydrochloride

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关于此项目

经验公式（希尔记法）:

C₃₆H₃₉NO₅ · HCl

化学文摘社编号:

646995-35-9

分子量:

602.16

UNSPSC Code:

12352200

PubChem Substance ID:

329825948

NACRES:

NA.77

MDL number:

MFCD28127267

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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属性

产品名称

Cinaciguat hydrochloride, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

OC(C(C=C1)=CC=C1CN(CCCCC(O)=O)CCC2=CC=CC=C2OCC3=CC=C(CCC4=CC=CC=C4)C=C3)=O.[H]Cl

InChI

1S/C36H39NO5.ClH/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28;/h1-5,8-11,15-22H,6-7,12-14,23-27H2,(H,38,39)(H,40,41);1H

InChI key

LLHMBJOVHATVSP-UHFFFAOYSA-N

说明

Biochem/physiol Actions

Cinaciguat activates sGC (soluble guanylate cyclase) independently of NO.

Cinaciguat activates sGC (soluble guanylate cyclase) independently of NO. Cinaciguat binds to sGC′s NO-sensory H-NOX domain when it is heme-depleted. Also, the compound Cinaciguat protects sGC from oxidation-induced ubiquitin-triggered degradation.

Cinaciguat, also known as BAY 58-2667, is a novel activator of guanylate cyclase. It is used in the treatment of acute decompensated heart failure (ADHF). It has been reported that cinaciguat possesses cardiovascular effects.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c