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SML1532

Cinaciguat hydrochloride

Name: Cinaciguat hydrochloride
Brand: SIGMA

≥98% (HPLC), guanylate cyclase activator, powder

别名:

4-[((4-Carboxybutyl){2-[(4-phenethylbenzyl)oxy]phenethyl}amino)methyl[benzoic]acid hydrochloride, 4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-benzoic acid hydrochloride, BAY 58-2667 hydrochloride, BAY582667 hydrochloride, UNII-59K0Y58UAD hydrochloride

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关于此项目

经验公式（希尔记法）:

C₃₆H₃₉NO₅ · HCl

化学文摘社编号:

646995-35-9

分子量:

602.16

UNSPSC Code:

12352200

PubChem Substance ID:

329825948

NACRES:

NA.77

MDL number:

MFCD28127267

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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属性

产品名称

Cinaciguat hydrochloride, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

OC(C(C=C1)=CC=C1CN(CCCCC(O)=O)CCC2=CC=CC=C2OCC3=CC=C(CCC4=CC=CC=C4)C=C3)=O.[H]Cl

InChI

1S/C36H39NO5.ClH/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28;/h1-5,8-11,15-22H,6-7,12-14,23-27H2,(H,38,39)(H,40,41);1H

InChI key

LLHMBJOVHATVSP-UHFFFAOYSA-N

说明

Biochem/physiol Actions

Cinaciguat, also known as BAY 58-2667, is a novel activator of guanylate cyclase. It is used in the treatment of acute decompensated heart failure (ADHF). It has been reported that cinaciguat possesses cardiovascular effects.

Cinaciguat activates sGC (soluble guanylate cyclase) independently of NO.

Cinaciguat activates sGC (soluble guanylate cyclase) independently of NO. Cinaciguat binds to sGC′s NO-sensory H-NOX domain when it is heme-depleted. Also, the compound Cinaciguat protects sGC from oxidation-induced ubiquitin-triggered degradation.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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