Merck
CN
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文件

安全信息

SML1537

Sigma-Aldrich

Cantharidin Ready Made Solution

0.1 mg/mL in DMSO

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别名:
2,3-二甲基-7-氧杂-双环[2.2.1]庚烷-2,3-二羧酸酐, Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione, 六氢-3α,7α-二甲基-4,7-环氧异苯并呋喃-1,3-二酮, 班蝥酸酐
经验公式（希尔记法）:
C10H12O4
CAS号:
56-25-7
分子量:
196.20
EC 号:
200-664-3

生物来源

insect

质量水平

200

形式

solution

浓度

0.1 mg/mL in DMSO

运输

ambient

储存温度

2-8°C

InChI

1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-

InChI key

DHZBEENLJMYSHQ-XCVPVQRUSA-N

相关类别

生化/生理作用

It is a component of mylabris, a traditional Chinese medicine. Cantharidin exhibits anti-tumor activity. In addition, cantharidin can work against multidrug-resistant cells. In the epidermis, it causes release of neutral serine proteases, leading to degeneration of the desmosmal plaque. This results in acantholysis and intraepidermal blistering as well as skin lysis. PP2A is involved in the cell cycle, cell death, growth and cell-fate determination.
Cantharidin inhibits protein phosphatase 2A.

其他说明

Stable for at least two years at 2-8° C.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

188.6 °F

闪点(°C)

87 °C

法规信息

高风险级别生物产品--毒素类产品

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Wei Li et al.
Cancer science, 101(5), 1226-1233 (2010-03-25)
Cantharidin is an active constituent of mylabris, a traditional Chinese medicine. It is a potent and selective inhibitor of protein phosphatase 2A (PP2A) that plays an important role in control of cell cycle, apoptosis, and cell-fate determination. Owing to its
Rolf Rauh et al.
Chinese medicine, 2, 8-8 (2007-07-06)
Herbal medicine is one of the forms of traditional medical practice. Traditional Chinese medicine (TCM) and traditional Vietnamese medicine (TVM) are well-known for their long-standing tradition of herbal medicine. Secreted by many species of blister beetle, most notably by the
L Moed et al.
Archives of dermatology, 137(10), 1357-1360 (2001-10-27)
Cantharidin, a vesicant produced by beetles in the order Coleoptera, has a long history in both folk and traditional medicine. In dermatology, topical cantharidin has long been used to treat warts and molluscum. In 1962, cantharidin lost Food and Drug

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