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SML1538

NMDI14

≥97% (HPLC), nonsense-mediated RNA decay inhibitor, powder

别名:

2-{[（6,7-二甲基-3-氧代-1,2,3,4-四氢-2-喹喔啉基）乙酰基]氨基} -4,5-二甲基-3-噻吩甲酸乙酯, 4,5-二甲基-2-[[2-（1,2,3,4-四氢-6,7-二甲基-3-氧代-2-喹喔啉基）乙酰基]氨基]-3-噻吩甲酸乙酯

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关于此项目

经验公式（希尔记法）:
C21H25N3O4S
化学文摘社编号:
307519-88-6
分子量:
415.51
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
powder
Quality level:
100
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产品名称

NMDI14, ≥97% (HPLC)

Quality Level

100

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 0.2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

[s]1c(c(c(c1C)C)C(=O)OCC)NC(=O)CC2Nc3c(cc(c(c3)C)C)NC2=O

InChI key

QRLPSNLBUMVXBL-UHFFFAOYSA-N

Application

NMDI14作为mRNA无义介导降解(NMD)抑制剂的应用：
  • 研究其对分化心肌细胞的影响
  • 研究其对斑马鱼pdzk1基因敲除胚胎的影响
  • 分析其对结直肠癌细胞凋亡的影响

Biochem/physiol Actions

NMDI14 是一种有效的无意义介导 RNA 衰变（NMD）抑制剂。 NMDI14 靶向 SMG7 蛋白的口袋，并破坏 SMG7-UPF1 相互作用。 NMDI14 可恢复具有提前终止密码子（PTC）突变的 p53 的细胞中的全长 p53 蛋白活性。
有效的无意义介导 RNA 衰变（NMD）抑制剂

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000368406
0000368405
0000368405
0000368406
0000355891

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Michael Bordonaro et al.
Journal of Cancer, 10(2), 287-292 (2019-02-06)
Deregulated Wnt signaling initiates most cases of colorectal cancer (CRC). Butyrate, a product of dietary fiber, hyperactivates Wnt signaling, resulting in induction of CRC cell apoptosis, which may in part explain the protective action of fiber. Nonsense mediated decay (NMD)
Greg H P Ngo et al.
Nature communications, 12(1), 3849-3849 (2021-06-24)
DNA-RNA hybrid structures have been detected at the vicinity of DNA double-strand breaks (DSBs) occurring within transcriptional active regions of the genome. The induction of DNA-RNA hybrids strongly affects the repair of these DSBs, but the nature of these structures
Xinyun Chen et al.
Nature communications, 12(1), 89-89 (2021-01-06)
The RNA-binding protein QKI belongs to the hnRNP K-homology domain protein family, a well-known regulator of pre-mRNA alternative splicing and is associated with several neurodevelopmental disorders. Qki is found highly expressed in developing and adult hearts. By employing the human
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全球贸易项目编号

货号GTIN
SML1538-25MG04061832637938
SML1538-5MG04061832637945