SML1542
Sitamaquine tosylate
≥98% (HPLC)
别名:
6-Methoxy-8-(6-diethylaminohexylamine)-4-methylquinoline tosylate, N-[6-(Diethylamino)hexyl]-6-methoxy-4-methylquinolin-8-amine tosylate, N1,N1-Diethyl-N6-(6-methoxy-4-methyl-8-quinolinyl)-1,6-hexanediamine tosylate, NSC 2452, WR-6026
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关于此项目
经验公式（希尔记法）:
C21H33N3O · C7H8O3S
化学文摘社编号:
分子量:
515.71
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
Sitamaquine tosylate, ≥98% (HPLC)
InChI
1S/C21H33N3O.C7H8O3S/c1-5-24(6-2)14-10-8-7-9-12-22-20-16-18(25-4)15-19-17(3)11-13-23-21(19)20;1-6-2-4-7(5-3-6)11(8,9)10/h11,13,15-16,22H,5-10,12,14H2,1-4H3;2-5H,1H3,(H,8,9,10)
SMILES string
CC1=C(C=C(OC)C=C2NCCCCCCN(CC)CC)C2=NC=C1.CC3=CC=C(S(=O)(O)=O)C=C3
InChI key
LOBPWLFCZDGYKW-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 15 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Sitamaquine is also known as WR-6026. It is used in the treatment of visceral leishmaniasis.
Sitamaquine is an orally active 8-aminoquinoline analog that exhibit antiplasmodial and antileishmanial activities.
Sitamaquine is an orally active 8-aminoquinoline analog that exhibit antiplasmodial and antileishmanial activities. Sitamaquine accumulates in Leishmania parasites. Sitamaquine potently inhibits respiratory chain complex II (succinate dehydrogenase), which leads to an apoptosis-like death of Leishmania parasites.
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
新产品
此项目有
Sitamaquine (GlaxoSmithKline/Walter Reed Army Institute)
Yeates C
Current Opinion in Investigational Drugs, 3(10), 1446-1452 (2002)
Diana Duarte et al.
Biomolecules, 10(12) (2020-12-05)
Chemotherapy plays a key role in breast cancer therapy, but drug resistance and unwanted side effects make the treatment less effective. We propose a new combination model that combines antineoplastic drugs and antimalarials for breast cancer therapy. Cytotoxic effects of
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